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1
Cardiac Response to Stress: Influence of Vortioxetine.心脏对应激的反应：伏硫西汀的影响。
Arq Bras Cardiol. 2025 Apr 14;122(2):e20250105. doi: 10.36660/abc.20250105. eCollection 2025.
2
The antidepressant drugs vortioxetine and duloxetine differentially and sex-dependently affect animal well-being, cognitive performance, cardiac redox status and histology in a model of osteoarthritis.在骨关节炎模型中，抗抑郁药物伏硫西汀和度洛西汀对动物的健康、认知表现、心脏氧化还原状态及组织学产生不同且有性别差异的影响。
Biomed Pharmacother. 2023 Oct;166:115360. doi: 10.1016/j.biopha.2023.115360. Epub 2023 Aug 31.
3
Chronic Vortioxetine Treatment Reduces Exaggerated Expression of Conditioned Fear Memory and Restores Active Coping Behavior in Chronically Stressed Rats.慢性文拉法辛治疗可减少慢性应激大鼠条件性恐惧记忆的过度表达，并恢复其积极应对行为。
Int J Neuropsychopharmacol. 2017 Apr 1;20(4):316-323. doi: 10.1093/ijnp/pyw105.
4
Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats.伏硫西汀可恢复因5-羟色胺耗竭或慢性间歇性冷应激而受损的大鼠逆向学习能力。
Int J Neuropsychopharmacol. 2014 Oct;17(10):1695-706. doi: 10.1017/S1461145714000571. Epub 2014 May 23.
5
Effect of Sertraline and Vortioxetine on Stress-Induced Brain Injury in Rats: Biochemical and Histopathological Evaluations.舍曲林和伏硫西汀对大鼠应激性脑损伤的影响：生化和组织病理学评估
Clin Neuropharmacol. 2024;47(6):213-217. doi: 10.1097/WNF.0000000000000615.
6
Chronic vortioxetine treatment improves the responsiveness to an acute stress acting through the ventral hippocampus in a glucocorticoid-dependent way.慢性文拉法辛治疗通过糖皮质激素依赖性方式改善腹侧海马体对急性应激的反应性。
Pharmacol Res. 2019 Apr;142:14-21. doi: 10.1016/j.phrs.2019.02.006. Epub 2019 Feb 5.
7
Effect of Vortioxetine on Cardiac Repolarization in Healthy Adult Male Subjects: Results of a Thorough QT/QTc Study.Vortioxetine 对健康成年男性受试者心脏复极的影响：一项全面的 QT/QTc 研究结果。
Clin Pharmacol Drug Dev. 2013 Oct;2(4):298-309. doi: 10.1002/cpdd.51. Epub 2013 Aug 16.
8
Hippocampal PPARα Plays a Role in the Pharmacological Mechanism of Vortioxetine, a Multimodal-Acting Antidepressant.海马体中的过氧化物酶体增殖物激活受体α在多模式抗抑郁药伏硫西汀的药理机制中发挥作用。
Front Pharmacol. 2021 Jun 15;12:673221. doi: 10.3389/fphar.2021.673221. eCollection 2021.
9
Activation of mTORC1 Signaling Cascade in Hippocampus and Medial Prefrontal Cortex Is Required for Antidepressant Actions of Vortioxetine in Mice.Vortioxetine 发挥抗抑郁作用需要激活小鼠海马体和内侧前额叶皮质中的 mTORC1 信号级联
Int J Neuropsychopharmacol. 2023 Oct 19;26(10):655-668. doi: 10.1093/ijnp/pyad017.
10
Vortioxetine reduces the development of pain-related behaviour in a knee osteoarthritis model in rats: Involvement of nerve growth factor (NGF) down-regulation.文拉法辛可减少大鼠膝骨关节炎模型中与疼痛相关行为的发展：涉及神经生长因子（NGF）下调。
Br J Pharmacol. 2024 Dec;181(24):5079-5093. doi: 10.1111/bph.17342. Epub 2024 Sep 19.

本文引用的文献

1
Vortioxetine's Therapeutic Potential: Cardiac Responses to Chronic Unpredictable Mild Stress in a Rat Model.伏硫西汀的治疗潜力：大鼠模型中慢性不可预测轻度应激的心脏反应
Arq Bras Cardiol. 2025 Feb 10;122(2):e20240159. doi: 10.36660/abc.20240159. eCollection 2025.
2
Stress and cardiovascular disease: an update.压力与心血管疾病：最新研究进展。
Nat Rev Cardiol. 2024 Sep;21(9):603-616. doi: 10.1038/s41569-024-01024-y. Epub 2024 May 2.
3
Effects of Chronic Mild Stress on Cardiac Autonomic Activity, Cardiac Structure and Renin-Angiotensin-Aldosterone System in Male Rats.慢性轻度应激对雄性大鼠心脏自主神经活动、心脏结构及肾素-血管紧张素-醛固酮系统的影响
Vet Sci. 2022 Sep 29;9(10):539. doi: 10.3390/vetsci9100539.
4
Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives.慢性温和应激范式作为一种大鼠抑郁症模型：事实、人为因素和未来展望。
Psychopharmacology (Berl). 2022 Mar;239(3):663-693. doi: 10.1007/s00213-021-05982-w. Epub 2022 Jan 24.
5
Brain-heart connections in stress and cardiovascular disease: Implications for the cardiac patient.脑心连接在压力和心血管疾病中的作用：对心脏病人的影响。
Atherosclerosis. 2021 Jul;328:74-82. doi: 10.1016/j.atherosclerosis.2021.05.020. Epub 2021 May 30.
6
Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?氧化应激与心血管疾病：治疗靶点仍未明？
Nutrients. 2019 Sep 4;11(9):2090. doi: 10.3390/nu11092090.
7
Chronic Unpredictable Mild Stress Promotes Atherosclerosis via HMGB1/TLR4-Mediated Downregulation of PPARγ/LXRα/ABCA1 in ApoE Mice.慢性不可预测轻度应激通过HMGB1/TLR4介导的ApoE小鼠中PPARγ/LXRα/ABCA1下调促进动脉粥样硬化。
Front Physiol. 2019 Mar 1;10:165. doi: 10.3389/fphys.2019.00165. eCollection 2019.
8
The chronic mild stress (CMS) model of depression: History, evaluation and usage.抑郁症的慢性轻度应激（CMS）模型：历史、评估与应用。
Neurobiol Stress. 2016 Aug 24;6:78-93. doi: 10.1016/j.ynstr.2016.08.002. eCollection 2017 Feb.
9
Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data.文拉法辛，一种具有多种作用机制的新型抗抑郁药：临床前和临床数据的综述。
Pharmacol Ther. 2015 Jan;145:43-57. doi: 10.1016/j.pharmthera.2014.07.001. Epub 2014 Jul 9.
10
Biological mechanisms in the relationship between depression and heart disease.抑郁症与心脏病关系中的生物学机制。
Neurosci Biobehav Rev. 2002 Dec;26(8):941-62. doi: 10.1016/s0149-7634(03)00003-4.

Cardiac Response to Stress: Influence of Vortioxetine.

作者信息

Carvalho Rodrigo Guimarães Vieira de, Mota Gustavo Augusto Ferreira, Sobral Milene Vitória Sampaio, Freire Ana Paula Coelho Figueira, Pacagnelli Francis Lopes

机构信息

Universidade do Oeste Paulista, Presidente Prudente, SP - Brasil.

Departamento de Clínica Médica - Faculdade de Medicina de Botucatu - Universidade Estadual Paulista (UNESP), São Paulo, SP - Brasil.

出版信息

Arq Bras Cardiol. 2025 Apr 14;122(2):e20250105. doi: 10.36660/abc.20250105. eCollection 2025.

DOI:10.36660/abc.20250105
PMID:40243715
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12040386/
Abstract
摘要