游离肿瘤DNA：膀胱癌尿路上皮癌诊断、监测及治疗决策的一项有前景的技术。
Cell-free Tumor DNA: a Promising Technology for Diagnosis, Surveillance and Therapeutic Decision in Urothelial Carcinoma of the Bladder.
作者信息
Martinez Lucas Motta, Ribeiro Lorena Cristina São Leão, Guidi Rodrigo Gilles, de Moraes Caio Mazzonetto Teofilo, Lyra Catharina Ribeiro, Liebl Bruno, Guimarães Vinicius Henrique Almeida, de Lima Richard Dobrucki, de Almeida Lucas Schenk, Suartz Caio Vinicius, Nahas William Carlos, Ribeiro-Filho Leopoldo Alves
机构信息
Division of Urology, Institute of Cancer of São Paulo, University of São Paulo, São Paulo, Brazil.
Federal University of Bahia, Salvador, Brazil.
出版信息
Curr Oncol Rep. 2025 Mar;27(3):225-235. doi: 10.1007/s11912-025-01648-4. Epub 2025 Feb 12.
PURPOSE OF REVIEW
This narrative review aims to discuss the latest evidence for cell-free tumor DNA (ctDNA) use in bladder cancer, future perspectives and challenges in implementing this technology in clinical practice.
RECENT FINDINGS
Recent papers describe promising findings regarding ctDNA analysis in blood samples and in urine of bladder cancer patients. This biomarker can be used as a diagnostic tool, in prognostic evaluation and as additional data for treatment indication and surveillance.
综述目的
本叙述性综述旨在讨论游离肿瘤DNA（ctDNA）在膀胱癌中应用的最新证据、在临床实践中应用该技术的未来前景和挑战。
最新发现
近期论文描述了关于膀胱癌患者血液样本和尿液中ctDNA分析的有前景的发现。这种生物标志物可用作诊断工具、用于预后评估以及作为治疗指征和监测的补充数据。
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