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血液学和肿瘤学疾病领域的肺动脉高压

Pulmonary Hypertension in the Field of Hematological and Oncological Diseases.

作者信息

Lichtblau Mona, Lador Frédéric, Lechartier Benoit, Ellegast Jana Maria, Pohle Susanne, Preiss Helga, Genecand Leon, Wick Carmen, Ulrich Silvia, Reimann Lena

机构信息

Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland.

Faculty of Medicine, University of Zurich, Zurich, Switzerland.

出版信息

Respiration. 2025;104(7):466-475. doi: 10.1159/000544126. Epub 2025 Feb 12.

Abstract

INTRODUCTION

Hematological and oncological diseases collectively affect a substantial number of patients. Pulmonary hypertension (PH) is recognized as a potential rare complication associated with these conditions, manifesting in various forms of PH and presenting with a range of symptoms. This review aimed to summarize recent research findings and enhance the understanding of the complex interactions between PH and hemato-oncological diseases.

METHODS

This narrative review synthesizes recent research findings to explore the interplay between PH and hematological or oncological diseases. A comprehensive search of relevant literature was conducted using PubMed.

RESULTS

The complexity of PH in this context arises from its multifactorial etiology, which can include direct effects of malignancies, treatment-related effects, and the impact of disease progression. The variability in how PH presents and progresses in patients with hematological diseases and neoplasms complicates its diagnosis and management. Accurate identification of PH alongside the underlying condition is crucial for enabling optimal treatment and improving overall survival. A multidisciplinary approach is essential to address these challenges effectively.

CONCLUSION

PH in hematologic and oncologic diseases can result from multiple causes. Following a systematic workup, a multidisciplinary approach to management is crucial to ensure optimal treatment and improve survival.

摘要

引言

血液学和肿瘤学疾病共同影响着大量患者。肺动脉高压(PH)被认为是与这些疾病相关的一种潜在罕见并发症,表现为各种形式的PH,并伴有一系列症状。本综述旨在总结近期研究结果,加深对PH与血液肿瘤学疾病之间复杂相互作用的理解。

方法

本叙述性综述综合近期研究结果,以探讨PH与血液学或肿瘤学疾病之间的相互作用。使用PubMed对相关文献进行了全面检索。

结果

在这种情况下,PH的复杂性源于其多因素病因,这可能包括恶性肿瘤的直接影响、治疗相关影响以及疾病进展的影响。PH在血液学疾病和肿瘤患者中的表现和进展的变异性使其诊断和管理变得复杂。准确识别PH以及潜在疾病对于实现最佳治疗和提高总体生存率至关重要。多学科方法对于有效应对这些挑战至关重要。

结论

血液学和肿瘤学疾病中的PH可能由多种原因引起。经过系统检查后,采用多学科管理方法对于确保最佳治疗和提高生存率至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb2e/12215174/f31ce9094e46/res-2025-0104-0007-544126_F01.jpg

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