[Acute isoniazid poisoning].

Acute isoniazid intoxication is characterised by high mortality and vomiting, seizures, coma and metabolic acidosis as main symptoms. Besides isoniazid, its metabolites may also cause neurotoxicity, as demonstrated in a patient. Delayed onset of neurotoxicity should be considered. The therapy of intoxication with special emphasis on high-dose vitamin B6 application is discussed.