Hartig P R, Krohn A M, Hirschman S A
Anal Biochem. 1985 Feb 1;144(2):441-6. doi: 10.1016/0003-2697(85)90139-3.
The synthesis and properties of 2-[125I]-lysergic acid diethylamide, the first 125I-labeled serotonin receptor ligand, are described. A novel microsynthesis apparatus was developed for this synthesis. The apparatus employs a micromanipulator and glass micro tools to handle microliter to nanoliter volumes on a microscope stage. This apparatus should be generally useful for the synthesis of radioligands and other compounds when limited amounts of material must be handled in small volumes.
本文描述了首个125I标记的血清素受体配体——2-[125I]-麦角酸二乙酰胺的合成及性质。为此合成开发了一种新型微量合成装置。该装置采用显微操作器和玻璃微工具，在显微镜载物台上处理微升至纳升体积的物质。当必须在小体积中处理有限量的材料时，该装置通常可用于放射性配体和其他化合物的合成。
