RNA结合蛋白：还是在乐队里演奏更好。
RNA-binding proteins: it's better to play in a band.
作者信息
Jeong Joshua, Hertel Klemens J, Shi Yongsheng
机构信息
Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, California 92697, USA.
Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, California 92697, USA
出版信息
Genes Dev. 2025 Mar 3;39(5-6):301-303. doi: 10.1101/gad.352667.125.
Alternative splicing (AS) is regulated by a myriad of RNA-binding proteins (RBPs) in a coordinated manner. However, most studies characterize RBPs individually. In this issue of , Peyda and colleagues (doi:10.1101/gad.352105.124) revealed how the LASR complex, consisting of multiple RBPs, regulates AS by recognizing multipart sequences. Their approach may be applicable to studying the combinatorial effects of other RBPs, which is critical for cracking the splicing code.
可变剪接（AS）由众多RNA结合蛋白（RBP）以协调的方式调控。然而，大多数研究都是单独对RBP进行表征。在本期《 》中，佩达及其同事（doi:10.1101/gad.352105.124）揭示了由多个RBP组成的LASR复合物如何通过识别多部分序列来调控AS。他们的方法可能适用于研究其他RBP的组合效应，这对于破解剪接密码至关重要。
Zotero 插件