Yao Haifeng, Su Gang, Hou Hua, Wang Jing, Sun Zhenmin, Li Zhaoxin, Zhai Zhaohui, Li Yuli
School of Clinical Medicine, Shandong Second Medical University, Weifang, 261053, China.
Plastic Surgery Institute, Shandong Second Medical University, Weifang, 261053, China.
Aesthetic Plast Surg. 2025 Apr;49(7):1833-1841. doi: 10.1007/s00266-025-04715-0. Epub 2025 Feb 12.
Polyacrylamide hydrogel (PAHG) is a new biomaterial that emerged in the last century and has been widely used in human filler procedures, such as injectable breast augmentation and facial contour improvement. However, as the implantation time of the material increases, various complications have been reported, which reflects that the safety of this material has not been adequately studied. Therefore, a more in-depth experimental analysis becomes particularly important.
We collected lesion tissues from six patients with PAHG facial injection. The lesion tissues were examined histologically and molecularly.
Complications caused by PAHG facial injection included pain, subcutaneous nodules, swelling and gel displacement. Western blot revealed decreased expression of neural tissue markers, and increased expression of macrophage markers and oxidative stress-related factors. The results of this study provide new insights into the mechanism and development of PAHG facial injection complications.
This report explores the possible mechanism of PAHG complications after facial injection from a new perspective of oxidative stress and inflammation for the first time, which provides a reference for researchers and clinicians to further understand the characteristics of materials and strictly control surgical indications to reduce complications.
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聚丙烯酰胺水凝胶（PAHG）是上世纪出现的一种新型生物材料，已广泛应用于人体填充手术，如注射隆胸和面部轮廓改善。然而，随着该材料植入时间的增加，已有各种并发症的报道，这表明该材料的安全性尚未得到充分研究。因此，进行更深入的实验分析尤为重要。
我们收集了6例PAHG面部注射患者的病变组织，对病变组织进行了组织学和分子学检查。
PAHG面部注射引起的并发症包括疼痛、皮下结节、肿胀和凝胶移位。蛋白质免疫印迹法显示神经组织标志物表达降低，巨噬细胞标志物和氧化应激相关因子表达增加。本研究结果为PAHG面部注射并发症的机制和发展提供了新的见解。
本报告首次从氧化应激和炎症的新角度探讨了PAHG面部注射后并发症的可能机制，为研究人员和临床医生进一步了解材料特性、严格控制手术适应症以减少并发症提供了参考。
本期刊要求作者为每篇适用循证医学排名的投稿指定证据水平。这排除了综述文章、书评以及涉及基础科学、动物研究、尸体研究和实验研究的手稿。有关这些循证医学评级的完整描述，请参阅目录或在线作者指南www.springer.com/00266 。
