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2005 - 2020年美国国家健康与营养检查调查中关节炎与膀胱过度活动症之间关联的新见解。

New insights into the association between arthritis and overactive bladder in NHANES 2005-2020.

作者信息

Sun Yifan, Sheng Jiayi, Wang Ke, Feng Ninghan

机构信息

Department of Urology, Jiangnan University Medical Center, Wuxi, China.

The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

出版信息

Sci Rep. 2025 Feb 13;15(1):5310. doi: 10.1038/s41598-025-89926-w.

Abstract

Arthritis and overactive bladder (OAB) are both common diseases, but the association between them remains unclear. The aim of our research is to investigate the possible link with regard to arthritis and OAB. Our study's data was sourced from the National Health and Nutrition Examination Survey (NHANES) database from 2005 to 2020. The Overactive Bladder Symptom Score (OABSS) was used to diagnose OAB, while the health questionnaire was used to diagnose arthritis. This research utilized weighted logistic regression to evaluate the correlation between OAB and arthritis. To ensure the robustness of these results, subgroup analyses along with interaction tests were performed. Our research comprised 24,436 participants. After correcting for all covariates, we found a positive association between arthritis and OAB (OR = 1.37, 95% CI: 1.22, 1.54). Stratified by arthritis type, there was a positive association between osteoarthritis (OA) and OAB (OR = 1.40, 95% CI: 1.22, 1.62). Rheumatoid arthritis (RA) (OR = 1.20, 95% CI: 0.99, 1.46) and psoriatic arthritis (OR = 1.40, 95% CI: 0.75, 2.60) were not significantly correlated with OAB. This research demonstrated that arthritis was closely related to OAB. Additional research is required to confirm this association.

摘要

关节炎和膀胱过度活动症(OAB)都是常见疾病,但它们之间的关联尚不清楚。我们研究的目的是调查关节炎与OAB之间可能存在的联系。我们研究的数据来自2005年至2020年的美国国家健康与营养检查调查(NHANES)数据库。采用膀胱过度活动症症状评分(OABSS)诊断OAB,同时使用健康问卷诊断关节炎。本研究利用加权逻辑回归评估OAB与关节炎之间的相关性。为确保这些结果的稳健性,进行了亚组分析和交互检验。我们的研究包括24436名参与者。校正所有协变量后,我们发现关节炎与OAB之间存在正相关(OR = 1.37,95%CI:1.22,1.54)。按关节炎类型分层,骨关节炎(OA)与OAB之间存在正相关(OR = 1.40,95%CI:1.22,1.62)。类风湿关节炎(RA)(OR = 1.20,95%CI:0.99,1.46)和银屑病关节炎(OR = 1.40,95%CI:0.75,2.60)与OAB无显著相关性。本研究表明关节炎与OAB密切相关。需要进一步的研究来证实这种关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44e8/11822026/7fb2de1079e3/41598_2025_89926_Fig2_HTML.jpg

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