Du Yuan-Zhuo, Liu Jia-Hao, Zheng Fu-Chun, Zhou Qiang, Guo Ju
Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Key Laboratory of Urinary System Diseases of Jiangxi Province, Nanchang, China.
Eur J Med Res. 2025 Apr 2;30(1):229. doi: 10.1186/s40001-025-02441-6.
The albumin-globulin ratio (AGR) is considered an important indicator reflecting an individual's immune function and nutritional status, and it is closely associated with various health conditions. However, despite its widely studied correlations in numerous health fields, the link between AGR and Overactive Bladder (OAB) is still not completely comprehended.
Data were sourced from the National Health and Nutrition Examination Survey (NHANES) database, selecting adult samples spanning from 2007 to 2018. Through comprehensive questionnaires and laboratory tests, we gathered data pertinent to OAB and the AGR. To explore the association between AGR levels and the likelihood of developing OAB, we utilized advanced statistical techniques, such as weighted multivariate logistic regression and restricted cubic spline (RCS) models. Furthermore, we carried out subgroup analyses to assess the uniformity of this association across various demographics.
After adjusting for relevant covariates, we discovered a marked negative correlation between AGR levels and the risk of OAB. As AGR increased, the incidence of OAB showed a declining trend (OR = 0.69; 95% CI 0.56-0.85). Furthermore, significant nonlinear dose-response relationship was observed between AGR levels and the risk of OAB (P < 0.001), and this association remained stable in stratified analyses.
Our results indicate that elevated AGR levels could be linked to a reduced risk of OAB. This observation highlights the potential role of AGR in assessing and preventing the occurrence of OAB.
白蛋白与球蛋白比值（AGR）被认为是反映个体免疫功能和营养状况的重要指标，且与多种健康状况密切相关。然而，尽管其在众多健康领域的相关性已得到广泛研究，但AGR与膀胱过度活动症（OAB）之间的联系仍未被完全理解。
数据来源于国家健康与营养检查调查（NHANES）数据库，选取2007年至2018年的成人样本。通过综合问卷和实验室检测，我们收集了与OAB和AGR相关的数据。为探究AGR水平与发生OAB可能性之间的关联，我们采用了先进的统计技术，如加权多变量逻辑回归和受限立方样条（RCS）模型。此外，我们还进行了亚组分析，以评估这种关联在不同人口统计学特征中的一致性。
在对相关协变量进行调整后，我们发现AGR水平与OAB风险之间存在显著的负相关。随着AGR的升高，OAB的发病率呈下降趋势（OR = 0.69；95% CI 0.56 - 0.85）。此外，AGR水平与OAB风险之间观察到显著的非线性剂量反应关系（P < 0.001），且这种关联在分层分析中保持稳定。
我们的结果表明，AGR水平升高可能与OAB风险降低有关。这一观察结果凸显了AGR在评估和预防OAB发生方面的潜在作用。
