Pourkhani Zahra, Jahanian Sadatmahalleh Shahideh, Moini Ashraf, Nasiri Malihe
Department of Reproductive Health and Midwifery, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Department of Gynecology and Obstetrics, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Sci Rep. 2025 Feb 12;15(1):5284. doi: 10.1038/s41598-025-89745-z.
Since a limited number of studies have investigated the different pattern of follicular distribution in the ovaries of PCOS patient, the present study was designed to evaluate the relationship of the follicular distribution pattern (FDP) in the ovaries and MetS as well as insulin resistance index, the sex hormones levels and menstrual status in women with PCOS diagnosis. This prospective study was carried out at Arash Women's Hospital (Tehran, Iran) from September 2023 to June 2024. All PCOS women who were referred for any gynecological examination were screened. The ultrasound images of polycystic ovarian morphology ovaries were further classified as having a peripheral cystic pattern (PCP) if the follicles were arranged at the periphery of the ovary, or a general cystic pattern (GCP) if the follicles were dispersed heterogeneously throughout the ovarian stroma. The association between the ultrasound follicular distribution patterns and the reproductive items (menstrual status, sex hormones levels and Ferriman-Gallwey score), as well as the metabolic features (insulin resistance index and the MetS rate) were evaluated. Of the 108 PCOS patients evaluated during the study, 51 patients were classified in the PCP ovaries group and 57 patients in the GCP ovaries group. There was no statistically significant difference in terms of women' age, body mass index, waist circumstance, and the Ferriman-Gallwey score between groups. The frequency of cases with oligo menorrhea in the PCP group was significantly higher than the GCP group (P = 0.006). However, no significant relationship was found between FDP and the baseline serum hormonal levels, total testosterone, and insulin resistance index as well as MetS rate and any components of MetS. No association was identified between the FDP and the rate of MetS, as well as other sex hormones, glucose, and lipids profiles in patients with PCOS; however, the PCP ovaries was linked to menstrual irregularities.
由于仅有有限的研究调查了多囊卵巢综合征（PCOS）患者卵巢中卵泡分布的不同模式，本研究旨在评估PCOS诊断女性的卵巢卵泡分布模式（FDP）与代谢综合征（MetS）以及胰岛素抵抗指数、性激素水平和月经状况之间的关系。这项前瞻性研究于2023年9月至2024年6月在阿拉什妇女医院（伊朗德黑兰）进行。对所有因任何妇科检查前来就诊的PCOS女性进行筛查。如果卵泡排列在卵巢周边，则多囊卵巢形态的卵巢超声图像进一步分类为具有周边囊性模式（PCP）；如果卵泡在整个卵巢基质中不均匀分布，则分类为一般囊性模式（GCP）。评估超声卵泡分布模式与生殖项目（月经状况、性激素水平和费里曼-盖尔韦评分）以及代谢特征（胰岛素抵抗指数和MetS发生率）之间的关联。在研究期间评估的108例PCOS患者中，51例患者被分类为PCP卵巢组，57例患者被分类为GCP卵巢组。两组之间在女性年龄、体重指数、腰围和费里曼-盖尔韦评分方面没有统计学上的显著差异。PCP组中月经过少病例的频率显著高于GCP组（P = 0.006）。然而，未发现FDP与基线血清激素水平、总睾酮、胰岛素抵抗指数以及MetS发生率和MetS的任何组成部分之间存在显著关系。在PCOS患者中，未发现FDP与MetS发生率以及其他性激素、血糖和血脂谱之间存在关联；然而，PCP卵巢与月经不规律有关。
