Zhang Nanjun, Li Bowen, Yan Yu, Shao Shuran, Hua Yimin, Duan Hongyu, Zhou Kaiyu, Wang Chuan, Liu Xiaoliang
Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
West China Medical School of Sichuan University, Chengdu, Sichuan, China.
Pediatr Rheumatol Online J. 2025 Feb 12;23(1):16. doi: 10.1186/s12969-025-01061-y.
The occurrence of arrhythmias as a complication of Kawasaki disease (KD) is extremely rare. Moreover, previous literature showed a low incidence of arrhythmias during the acute phase of KD, and the majority occurred in the subacute and chronic phases. To date, we have found only 17 sporadically reported global cases in the available literature.
We present the first documented case of an infant with KD complicated with supraventricular tachycardia (Atrioventricular reentrant tachycardia) during the acute phase. The arrhythmia resolved promptly after the combination therapy of intravenous Immunoglobulin (IVIG) and steroids during the acute phase since the inflammation subsided. Additionally, we conducted a review and summary of cases involving KD-related arrhythmias.
KD rarely causes arrhythmias, which might be associated with myocarditis and myocardial ischemia attributed to scar formation and/or excessive inflammatory factors damaging the conduction system. Strengthening the early identification and management of complications in patients with KD and personalized follow-up strategies for high-risk children during the chronic phase can enhance patients' prognosis.
心律失常作为川崎病（KD）的一种并发症极为罕见。此外，既往文献显示KD急性期心律失常的发生率较低，且大多数发生在亚急性期和慢性期。迄今为止，在现有文献中我们仅发现17例全球散发性报道的病例。
我们报告首例记录在案的KD婴儿在急性期并发室上性心动过速（房室折返性心动过速）的病例。由于炎症消退，在急性期静脉注射免疫球蛋白（IVIG）和类固醇联合治疗后，心律失常迅速得到缓解。此外，我们对KD相关心律失常的病例进行了回顾和总结。
KD很少引起心律失常，这可能与心肌炎和心肌缺血有关，其归因于瘢痕形成和/或过度的炎症因子损害传导系统。加强KD患者并发症的早期识别和管理，以及对慢性期高危儿童采取个性化的随访策略，可以改善患者的预后。
