Amadei Matteo, Polticelli Fabio, Musci Giovanni, Bonaccorsi di Patti Maria Carmela
Department of Biochemical Sciences 'A. Rossi Fanelli', Sapienza University of Rome, 00185 Rome, Italy.
Department of Sciences, University Roma Tre, 00146 Rome, Italy.
Int J Mol Sci. 2025 Jan 21;26(3):875. doi: 10.3390/ijms26030875.
Transport of iron across the cell membrane is a tightly controlled process carried out by specific proteins in all living cells. In yeast and in mammals, a system formed by an enzyme with ferroxidase activity coupled to a membrane transporter supports iron uptake or iron efflux, respectively. Ferroxidase belongs to the family of blue multicopper oxidases, enzymes able to couple the one-electron oxidation of substrate(s) to full reduction of molecular oxygen to water. On the other hand, the permeases are widely different and are specific to Fe and Fe in yeast and multicellular organisms, respectively. This review will describe the yeast and human ferroxidase-permease systems, highlighting similarities and differences in structure, function and regulation of the respective protein components.
铁穿过细胞膜的转运是一个由所有活细胞中的特定蛋白质严格控制的过程。在酵母和哺乳动物中，由具有铁氧化酶活性的酶与膜转运蛋白形成的系统分别支持铁的摄取或铁的外排。铁氧化酶属于蓝色多铜氧化酶家族，这类酶能够将底物的单电子氧化与分子氧完全还原为水的过程偶联起来。另一方面，通透酶差异很大，在酵母和多细胞生物中分别对Fe²⁺和Fe³⁺具有特异性。本综述将描述酵母和人类的铁氧化酶 - 通透酶系统，突出各自蛋白质组分在结构、功能和调控方面的异同。
