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青春期经历的慢性不可预测轻度应激的长期影响可能因生物性别而异。

The Long-Term Effects of Chronic Unpredictable Mild Stress Experienced During Adolescence Could Vary Depending on Biological Sex.

作者信息

Shirokova Olesya M, Kuzmina Daria M, Zaborskaya Olga G, Shchelchkova Natalia A, Kozliaeva Elizaveta V, Korotchenko Svetlana A, Pershin Vladimir I, Vasilchikov Petr I, Mukhina Irina V

机构信息

Federal State Budgetary Educational Institution of Higher Education «Privolzhsky Research Medical University» of the Ministry of Health of the Russian Federation, 603005 Nizhny Novgorod, Russia.

Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, 23 Gagarina Ave., 602022 Nizhny Novgorod, Russia.

出版信息

Int J Mol Sci. 2025 Jan 31;26(3):1251. doi: 10.3390/ijms26031251.

DOI:10.3390/ijms26031251
PMID:39941015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11818548/
Abstract

Sex differences in the neurobiology of responses to chronic stress have been widely discussed but remain poorly understood. We found that chronic unpredictable mild stress (CUMS) experienced during adolescence induced different behavioral patterns in adult males and females. Immunohistochemical analysis of the CA1 field of the dorsal and ventral hippocampus revealed no quantitative or morphological changes in astrocytes in the long term after CUMS. Real-time PCR analysis showed no increase in the expression level of SigmaR1 after CUMS relative to individual housekeeping genes. Analysis of mouse cerebral cortex homogenates showed that IL-1β levels only decreased after CUMS in males. However, the SigmaR1 levels were significantly higher in the CUMS groups than in the control groups in both sexes. It can be concluded that biological sex and age influence the response to CUMS, although not in all cases. Further studies are needed to understand the effects of chronic stress on males and females. This is important because men and women have different risks for stress and mental disorders.

摘要

慢性应激反应神经生物学中的性别差异已被广泛讨论，但仍知之甚少。我们发现，青春期经历的慢性不可预测轻度应激（CUMS）在成年雄性和雌性中诱发了不同的行为模式。对背侧和腹侧海马CA1区的免疫组织化学分析显示，CUMS长期后星形胶质细胞无数量或形态变化。实时PCR分析显示，与单个看家基因相比，CUMS后SigmaR1的表达水平没有增加。对小鼠大脑皮质匀浆的分析表明，只有雄性小鼠在CUMS后IL-1β水平下降。然而，CUMS组的SigmaR1水平在两性中均显著高于对照组。可以得出结论，生物性别和年龄会影响对CUMS的反应，尽管并非在所有情况下都是如此。需要进一步研究以了解慢性应激对男性和女性的影响。这一点很重要，因为男性和女性面临压力和精神障碍的风险不同。

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