Vlad Nutu, Andriesi-Rusu Florina Delia, Chicos Andrei, Trofin Ana Maria, Cadar Ramona, Zabara Mihai Lucian, Ciobanu Delia, Costache Mircea, Lupascu-Ursulescu Corina, Vasilescu Alin Mihai, Bradea Costel, Blaj Mihaela, Lovin Oana Maria, Ciumanghel Adi Ionut, Crumpei Felicia, Lupascu Cristian Dumitru
First Surgical Clinic, "St. Spiridon" Hospital Iasi, Independentei str, no 1, 700111 Iasi, Romania.
Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania.
Diagnostics (Basel). 2025 Jan 23;15(3):268. doi: 10.3390/diagnostics15030268.
Neuroendocrine tumors are tumors that can develop in any organ but show a predilection for the pancreas. These can be secreting or non-secreting tumors, or they can be well differentiated or poorly differentiated, or neuroendocrine carcinomas. Surgical treatment is the only treatment with curative intent, but postoperatively, it shows an increased incidence of postoperative pancreatic fistulas. We carried out a retrospective study which included 26 patients with neuroendocrine tumors and neuroendocrine carcinomas, for whom we performed cephalic duodenopancreatectomies, distal pancreatic resections or enucleation. In our study group, the incidence of pancreatic fistulas was 28%, and a series of risk factors such as the type of surgery (duodenopancreatectomy and enucleation were associated with the highest incidence of POPF), histological type (pancreatic neuroendocrine carcinomas were associated with lowest incidence of POPF), obesity (the incidence of POPF was double in the obese group), functioning tumors (with = 0.032 and AUC = 746) and dynamic hemoglobin value (AUC = 705 shows a good predicting power, with a cutoff value = 1.8 drop hemoglobin) were indicated. Neuroendocrine tumors show a predisposition for the occurrence of postoperative complications, especially postoperative pancreatic fistulas. There are multiple risk factors that interact in the production of postoperative complications.
神经内分泌肿瘤是可发生于任何器官但好发于胰腺的肿瘤。这些肿瘤可以是分泌性或非分泌性肿瘤，也可以是高分化或低分化的，或是神经内分泌癌。手术治疗是唯一具有治愈意图的治疗方法，但术后胰瘘的发生率会增加。我们进行了一项回顾性研究，纳入了26例神经内分泌肿瘤和神经内分泌癌患者，对他们实施了胰头十二指肠切除术、胰腺远端切除术或肿瘤摘除术。在我们的研究组中，胰瘘的发生率为28%，并且指出了一系列危险因素，如手术类型（十二指肠胰腺切除术和肿瘤摘除术与术后胰瘘的最高发生率相关）、组织学类型（胰腺神经内分泌癌与术后胰瘘的最低发生率相关）、肥胖（肥胖组术后胰瘘的发生率是对照组的两倍）、功能性肿瘤（P = 0.032，曲线下面积 = 746）和动态血红蛋白值（曲线下面积 = 705显示出良好的预测能力，截断值 = 血红蛋白下降1.8）。神经内分泌肿瘤术后易发生并发症，尤其是术后胰瘘。术后并发症的发生存在多种相互作用的危险因素。
