Yapar Gizem, Köksal Muammer Osman, Sarsar Kutay, Soğuksu Pınar, Demirci Mehmet, Yurtseven Eray, Kır Murat Hakan, Allahverdiyeva Aytaj, Çağatay Arif Atahan, Ağaçfidan Ali, Kırkoyun Uysal Hayriye
Department of Medical Microbiology, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey.
Department of Medical Microbiology, Institute of Health Sciences, Istanbul University, 34126 Istanbul, Turkey.
Diagnostics (Basel). 2025 Feb 4;15(3):365. doi: 10.3390/diagnostics15030365.
subsp. is a spirochete that only causes disease in humans as the causative agent of syphilis. HIV and syphilis have common transmission routes. In the present study, our aim was to evaluate the presence of syphilis coinfection in people living with HIV using conventional and reverse algorithms and to investigate its effects on laboratory parameters. : The traditional algorithm for syphilis begins testing with the non-treponemal test. If the non-treponemal test is reactive, a treponemal test is then used to confirm syphilis infection. The reverse algorithm for syphilis begins testing with the treponemal test. If this test is reactive, then a non-treponemal test is performed. When the non-treponemal test is non-reactive, a second treponemal test is performed. : A total of 200 patients were included in the study. While 22 patients were determined to be syphilis-positive using the traditional algorithm, 37 patients were determined to be syphilis-positive using the reverse algorithm. Most of the patients who had syphilis coinfection were homosexual. It was found that syphilis coinfection had no effects on CD4+ T-lymphocyte and CD8+ T-lymphocyte values, CD4/CD8 rates, and HIV RNA amounts. People living with HIV must be screened and followed up for syphilis and other sexually transmitted diseases at certain intervals.
亚种是一种螺旋体，作为梅毒的病原体仅在人类中引起疾病。HIV和梅毒有共同的传播途径。在本研究中，我们的目的是使用传统算法和反向算法评估HIV感染者中梅毒合并感染的情况，并研究其对实验室参数的影响。：梅毒的传统算法从非梅毒螺旋体试验开始检测。如果非梅毒螺旋体试验呈阳性反应，则使用梅毒螺旋体试验来确诊梅毒感染。梅毒的反向算法从梅毒螺旋体试验开始检测。如果该试验呈阳性反应，则进行非梅毒螺旋体试验。当非梅毒螺旋体试验为阴性时，进行第二次梅毒螺旋体试验。：本研究共纳入200例患者。使用传统算法确定22例患者梅毒呈阳性，使用反向算法确定37例患者梅毒呈阳性。大多数合并梅毒感染的患者为同性恋者。研究发现，梅毒合并感染对CD4 + T淋巴细胞和CD8 + T淋巴细胞值、CD4/CD8比率及HIV RNA量没有影响。HIV感染者必须定期进行梅毒和其他性传播疾病的筛查及随访。
