Halapas Antonios, Cokkinos Dennis V
Department of Interventional Cardiologist and THV Program, Athens Medical Center, 11526 Athens, Greece.
Clinical, Translational and Experimental Surgery Research Centre, Biomedical Research Foundation Academy of Athens, 4, Soranou Ephessiou Str., 11527 Athens, Greece.
J Clin Med. 2025 Jan 29;14(3):903. doi: 10.3390/jcm14030903.
Calcific aortic stenosis (CAS) is currently recognized as the third most frequent cardiovascular disorder in persons aged above 60 years, after atherosclerotic disease and hypertension, and together with its precursor aortic sclerosis it has been found in more than 30% of elderly individuals. CAS is an active multifactorial process characterized by a progressive fibro-calcific remodeling and thickening of the AV leaflets caused by hemodynamic flow factors, genetic factors, lipoprotein deposition, oxidation, chronic inflammation, immunomodulators, and finally osteoblastic transformation of cardiac. Herein a comprehensive state-of-the-art paper is presented regarding the underlying pathophysiological mechanisms of CAS and the potential preventive strategies as an alternative to surgical and interventional treatment.
钙化性主动脉瓣狭窄（CAS）目前被认为是60岁以上人群中第三常见的心血管疾病，仅次于动脉粥样硬化疾病和高血压，并且连同其前驱病变主动脉硬化一起，在超过30%的老年人中被发现。CAS是一个活跃的多因素过程，其特征是由血流动力学因素、遗传因素、脂蛋白沉积、氧化、慢性炎症、免疫调节剂，最终是心脏的成骨细胞转化导致主动脉瓣小叶进行性纤维钙化重塑和增厚。本文就CAS的潜在病理生理机制以及作为手术和介入治疗替代方案的潜在预防策略进行了全面的最新综述。
