Boisvert P, Wasserman S I, Schiff M, Ryan A F
Ann Otol Rhinol Laryngol. 1985 Mar-Apr;94(2 Pt 1):212-6. doi: 10.1177/000348948509400224.
It has been suggested that immune responses and resultant generation or release of inflammatory mediators play a role in otitis media with effusion (OME). To explore the potential of one such mediator to contribute to OME, the effects of histamine injected into the middle ear cavity were examined. Injection of histamine into the guinea pig middle ear was found to produce dilation and endothelial disjunction in capillaries, leading to striking mucosal edema and effusion which persisted for at least several hours. This response could be partially blocked by pretreatment with either H1 or H2 antihistamines. It is suggested that histamine released during immune responses in the middle ear may contribute to the formation of effusion and submucosal edema as observed in OME.
有人提出，免疫反应以及由此产生或释放的炎症介质在分泌性中耳炎（OME）中起作用。为了探究其中一种介质对OME的潜在影响，研究了向中耳腔注射组胺的效果。向豚鼠中耳注射组胺会导致毛细血管扩张和内皮分离，进而引起明显的粘膜水肿和积液，且这种情况至少持续数小时。用H1或H2抗组胺药预处理可部分阻断这种反应。提示中耳免疫反应过程中释放的组胺可能促成了OME中观察到的积液和粘膜下水肿的形成。
