Toloza Freddy J K, Filie Armando, Raffeld Mark, Kebebew Electron, Klubo-Gwiezdzinska Joanna, Gubbi Sriram
Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Department of Cytopathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
JCEM Case Rep. 2025 Feb 12;3(3):luaf018. doi: 10.1210/jcemcr/luaf018. eCollection 2025 Mar.
Thyroid nodules are one of the most commonly encountered conditions in clinical endocrinology. Most thyroid nodules are of epithelial origin. However, primary thyroid mesenchymal tumors (TMTs), arising from the mesenchymal tissue, are being increasingly recognized. More than 20 different forms of benign and malignant TMTs have been described in the literature. Thyroid schwannoma is an extremely rare type of TMT, with only a few cases reported to date, accounting for less than 1% of all schwannomas. It primarily affects adults, with no significant sex predilection, and is often discovered incidentally during evaluation for thyroid nodules. Due to its rarity, the clinical presentation and natural history remain poorly understood, underscoring the importance of histopathological examination for accurate diagnosis and management. We describe a case of a patient with thyroid schwannoma who was diagnosed and managed at our center, contributing valuable insights to the limited body of knowledge on this rare entity. This is followed by a detailed description of the clinical features, diagnosis, and management of thyroid schwannomas.
甲状腺结节是临床内分泌学中最常见的病症之一。大多数甲状腺结节起源于上皮组织。然而,起源于间叶组织的原发性甲状腺间叶肿瘤(TMTs)正越来越受到人们的认识。文献中已描述了20多种不同形式的良性和恶性TMTs。甲状腺神经鞘瘤是一种极其罕见的TMT类型,迄今为止仅有少数病例报道,占所有神经鞘瘤的比例不到1%。它主要影响成年人,无明显性别倾向,常在评估甲状腺结节时偶然发现。由于其罕见性,其临床表现和自然病史仍知之甚少,这凸显了组织病理学检查对于准确诊断和管理的重要性。我们描述了一例在我们中心诊断和治疗的甲状腺神经鞘瘤患者,为关于这个罕见实体的有限知识体系提供了有价值的见解。随后详细描述了甲状腺神经鞘瘤的临床特征、诊断和治疗。