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在口服免疫治疗前使用奥马珠单抗进行快速食物脱敏治疗。

Rapid food desensitization associated with omalizumab before oral immunotherapy.

作者信息

Giavina-Bianchi Bruna, Giavina-Bianchi Pedro

机构信息

Clinical Immunology and Allergy Division, University of São Paulo School of Medicine, Brazil.

出版信息

World Allergy Organ J. 2025 Jan 28;18(2):101032. doi: 10.1016/j.waojou.2025.101032. eCollection 2025 Feb.

Abstract

In this report, we propose an innovative approach to managing patients with food-induced anaphylaxis by performing rapid food desensitization alongside the use of omalizumab as an introductory step to oral immunotherapy. This combined strategy aims to enhance both the safety and effectiveness of the process, which seeks to induce immunological tolerance to food allergens, while reducing the risk of severe allergic reactions during treatment. The use of omalizumab helps prevent anaphylaxis and improves the patient's ability to tolerate the allergen. Rapid desensitization offers significant time and cost savings. As more scientific evidence supports rapid food desensitization, it could become a valuable tool for clinicians managing food-induced anaphylaxis, offering a promising avenue for the treatment of food allergies, especially in complex cases.

摘要

在本报告中,我们提出了一种创新方法来管理食物诱导性过敏反应患者,即在使用奥马珠单抗的同时进行快速食物脱敏,作为口服免疫疗法的入门步骤。这种联合策略旨在提高该过程的安全性和有效性,该过程旨在诱导对食物过敏原的免疫耐受,同时降低治疗期间严重过敏反应的风险。奥马珠单抗的使用有助于预防过敏反应,并提高患者耐受过敏原的能力。快速脱敏可显著节省时间和成本。随着越来越多的科学证据支持快速食物脱敏,它可能成为临床医生管理食物诱导性过敏反应的宝贵工具,为食物过敏的治疗提供了一条有前景的途径,尤其是在复杂病例中。

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Omalizumab for the Treatment of Multiple Food Allergies.奥马珠单抗治疗多种食物过敏。
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Biologicals in IgE-mediated food allergy.IgE介导的食物过敏中的生物制品
Curr Opin Allergy Clin Immunol. 2023 Jun 1;23(3):205-209. doi: 10.1097/ACI.0000000000000900. Epub 2023 Mar 28.
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