Kouhzad Mobina, Götz Friedrich, Navidifar Tahereh, Taki Elahe, Ghamari Mahsa, Mohammadzadeh Roghayeh, Seyedolmohadesin Maryam, Bostanghadiri Narjess
Department of Genetics, Faculty of Science, Islamic Azad University North Tehran Branch, Tehran, Iran.
Department of Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen, Tübingen, Germany.
Front Oncol. 2025 Jan 29;15:1514872. doi: 10.3389/fonc.2025.1514872. eCollection 2025.
Secondary bile acids (SBAs), which are metabolites produced by gut microbiota, have been implicated in both carcinogenic and anticancer processes. This review explores the dual role of SBAs, focusing on their molecular mechanisms and biological effects. The carcinogenic activities of SBAs include DNA damage, promotion of oxidative stress, and modulation of signaling pathways that drive tumorigenesis. Conversely, some SBAs exhibit anticancer properties by inducing apoptosis, inhibiting cell proliferation, and modulating immune responses. The article also discusses the complex interplay between SBAs and the host's genetic and environmental factors, highlighting potential therapeutic implications and the need for targeted strategies to mitigate risks while harnessing beneficial effects. A comprehensive understanding of the delicate equilibrium between the deleterious and salutary impacts of SBAs has the potential to facilitate the development of innovative cancer prevention and treatment methodologies.
次级胆汁酸（SBAs）是肠道微生物群产生的代谢产物，在致癌和抗癌过程中均有涉及。本综述探讨了SBAs的双重作用，重点关注其分子机制和生物学效应。SBAs的致癌活性包括DNA损伤、促进氧化应激以及调节驱动肿瘤发生的信号通路。相反，一些SBAs通过诱导细胞凋亡、抑制细胞增殖和调节免疫反应表现出抗癌特性。本文还讨论了SBAs与宿主遗传和环境因素之间的复杂相互作用，强调了潜在的治疗意义以及采取针对性策略来降低风险并利用有益作用的必要性。全面了解SBAs有害和有益影响之间的微妙平衡，有可能促进创新的癌症预防和治疗方法的发展。
