泛素化和去泛素化在癌症脂质代谢中的作用。

The role of ubiquitination and deubiquitination in cancer lipid metabolism.

作者信息

Xu Yongkang, Zeng Jiayu, Fu Shumin, Liu Kan, Mao Ye, Tao Si, Wu Jianbing

机构信息

Department of Oncology, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Department of Pediatric Surgery, Jiangxi Provincial Children's Medical Center, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, China.

出版信息

Front Oncol. 2025 Jan 29;15:1464914. doi: 10.3389/fonc.2025.1464914. eCollection 2025.

DOI:10.3389/fonc.2025.1464914

PMID:39944823

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11813751/

Abstract

The ubiquitin-proteasome system (UPS) is one of the main degradation systems within cells, catalyzing the tagging of proteins for degradation by ubiquitin molecules, which are then recognized and degraded by the proteasome. Lipid metabolism plays a crucial role in cellular energy metabolism and is closely associated with the occurrence and development of cancers. Recent research indicates that cancer lipid metabolism is regulated by intracellular proteins, including ubiquitination modifications. This review will explore the role of ubiquitination in regulating cancer lipid metabolism, summarize the latest research progress, and propose potential therapeutic strategies.

摘要

泛素-蛋白酶体系统（UPS）是细胞内主要的降解系统之一，催化蛋白质被泛素分子标记以便降解，然后这些蛋白质被蛋白酶体识别并降解。脂质代谢在细胞能量代谢中起着关键作用，并且与癌症的发生和发展密切相关。最近的研究表明，癌症脂质代谢受细胞内蛋白质调控，包括泛素化修饰。本综述将探讨泛素化在调节癌症脂质代谢中的作用，总结最新研究进展，并提出潜在的治疗策略。