Gou Boyun, Chen Guoqing, Huang Shicong, Ning Na, Gu Qian, Duan Shuai, Du Yuhua, Nan Yi, Yuan Ling
College of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
Key Laboratory of Ningxia Ethnomedicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
Front Oncol. 2025 Jan 29;15:1489974. doi: 10.3389/fonc.2025.1489974. eCollection 2025.
Cancer is one of the most serious public health challenges in the world. The number of new and fatal patients with cancer continues to increase every year, which poses a serious threat to human health. Although there are effective treatments such as radiotherapy and chemotherapy for cancers, they are often accompanied by serious side effects. With the development of the pharmaceutical industry, there is a gradual desire to develop low-toxicity and effective anticancer drugs from traditional Chinese herbs. Due to its "homology of medicine and food," jujube is one of the traditional Chinese herbs that is extensively used in China. In addition, jujube has received much attention around the world for its excellent pharmacological effects and food value. This article reviews the anticancer effects of a fruit, food, and drug, jujube, which have been shown in current studies, and analyzes its therapeutic mechanism, active ingredients, extraction and isolation methods, as well as its synergistic and attenuation performance in cancer. This will further promote the progress of natural medicine's anti-cancer effect.
癌症是世界上最严峻的公共卫生挑战之一。每年新增癌症患者和癌症死亡患者的数量持续增加，这对人类健康构成了严重威胁。尽管对于癌症有放疗和化疗等有效治疗方法，但它们常常伴有严重的副作用。随着制药行业的发展，人们逐渐希望从传统中药中开发出低毒有效的抗癌药物。由于其“药食同源”，枣是在中国广泛使用的传统中药之一。此外，枣因其出色的药理作用和食用价值而在全球受到广泛关注。本文综述了目前研究中已表明的一种既是水果、食物又是药物的枣的抗癌作用，并分析了其治疗机制、活性成分、提取分离方法，以及其在癌症中的协同和减毒性能。这将进一步推动天然药物抗癌作用的进展。
