父母高敏C反应蛋白与子代高血压之间的关联：一项代际研究。

Association between parental high-sensitive C-reactive protein and hypertension in offspring: an intergenerational study.

作者信息

Yang Xuemei, Cui Feipeng, Chen Shuohua, Wang Guodong, Wu Shouling, Cui Liufu

机构信息

Department of Rheumatic Disease, Kailuan General Hospital, Tangshan, China.

Graduate School, North China University of Science and Technology, Tangshan, China.

出版信息

Clin Hypertens. 2025 Feb 1;31:e6. doi: 10.5646/ch.2025.31.e6. eCollection 2025.

DOI:10.5646/ch.2025.31.e6

PMID:39944935

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11800284/

Abstract

BACKGROUND

Although the association between C-reactive protein (CRP) and hypertension has been acknowledged, the associations between parental high-sensitive CRP (hs-CRP) levels and offspring hypertension remain unexplored. To investigate the relationship between parental and offspring hs-CRP levels, as well as the association between parental hs-CRP levels and offspring hypertension.

METHODS

We included 6,848 father-offspring and 1,588 mother-offspring pairs from the Kailuan study. Time-weighted average hs-CRP (TWA-CRP) was calculated by cumulative hs-CRP/Time. Hypertension were defined as systolic blood pressure (BP) ≥ 140 mmHg and/or diastolic BP ≥ 90 mmHg. The generalized estimating equation model was used to explored the relationship between parental TWA-CRP and offspring TWA-CRP, and the association between parental TWA-CRP and offspring hypertension. The Cox proportional hazard model was applied to examine the relationship between offspring TWA-CRP and hypertension risk.

RESULTS

The regression coefficient and 95% confidence intervals (CIs) for offspring TWA-CRP were 0.50 (0.38-0.62) in father-offspring pairs and 0.53 (0.29-0.76) in mother-offspring pairs with high parental TWA-CRP. The odds ratios (ORs) and 95% CIs for offspring hypertension were 1.30 (1.11-1.52) in father-offspring pairs and 1.32 (0.95-1.84) in mother-offspring pairs with high parental TWA-CRP. When both parent and offspring had a high TWA-CRP, the ORs (95% CIs) for offspring hypertension were 1.92 (1.43-2.56) in father-offspring pairs and 2.44 (1.35-4.35) in mother-offspring pairs. The hazard ratios and 95% CIs for offspring hypertension were 1.43 (1.15-1.76) in father-offspring pairs and 2.48 (1.18-5.22) in mother-offspring pairs with high offspring TWA-CRP.

CONCLUSIONS

Parental high TWA-CRP may increase the risk of offspring hypertension.

TRIAL REGISTRATION

Chinese Clinical Trial Registry Identifier: ChiCTR2000029767.

摘要

背景

尽管C反应蛋白（CRP）与高血压之间的关联已得到认可，但父母高敏CRP（hs-CRP）水平与子代高血压之间的关联仍未得到探索。旨在研究父母与子代hs-CRP水平之间的关系，以及父母hs-CRP水平与子代高血压之间的关联。

方法

我们纳入了开滦研究中的6848对父子对和1588对母子对。通过累积hs-CRP/时间计算时间加权平均hs-CRP（TWA-CRP）。高血压定义为收缩压（BP）≥140 mmHg和/或舒张压BP≥90 mmHg。使用广义估计方程模型探讨父母TWA-CRP与子代TWA-CRP之间的关系，以及父母TWA-CRP与子代高血压之间的关联。应用Cox比例风险模型检验子代TWA-CRP与高血压风险之间的关系。

结果

在父母TWA-CRP高的父子对中，子代TWA-CRP的回归系数和95%置信区间（CI）为0.50（0.38-0.62），在母子对中为0.53（0.29-0.76）。在父母TWA-CRP高的父子对中，子代高血压的比值比（OR）和95%CI为1.30（1.11-1.52），在母子对中为1.32（0.95-1.84）。当父母和子代的TWA-CRP都高时，在父子对中，子代高血压的OR（95%CI）为1.92（1.43-2.56），在母子对中为2.44（1.35-4.35）。在子代TWA-CRP高的父子对中，子代高血压的风险比和95%CI为1.43（1.15-1.76），在母子对中为2.48（1.18-5.22）。