Dong F, Howard A G, Herring A H, Adair L S, Thompson A L, Popkin B M, Aiello A E, Zhang B, Gordon-Larsen P
Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, USA.
Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, USA.
Pediatr Obes. 2017 Oct;12(5):422-430. doi: 10.1111/ijpo.12160. Epub 2016 Jun 8.
China has the world's highest diabetes prevalence, which along with hypertension and inflammation continues to grow particularly among children. Little is known about the strength of the association of these cardiometabolic risk factors between parents and their children; thus, the potential of household-based strategies to reduce risk is unknown.
The objective of the study is to examine the parent-child association for haemoglobin A1c (HbA1c), blood pressure (BP) and C-reactive protein (CRP) in a large, geographically diverse Chinese sample.
In 940 parent-child pairs (children aged 7-17 years) who participated in the 2009 China Health and Nutrition Survey, we measured each individual's HbA1c and CRP using fasting blood and BP. We used sex-specific random-effects linear regression to examine the parent-child association for these risk factors, accounting for within-family clustering.
Child's HbA1c was positively associated with parental HbA1c. Beta coefficients ranged from 0.06 (95% CI 0.03-0.12) for father-daughter to 0.43 (95% CI 0.28-0.58) for mother-son pairs. We also detected a positive mother-daughter association for BP and positive father-child associations for CRP.
The statistically significant parent-child association for HbA1c, BP and CRP in Chinese families suggests that household-based interventions could be useful for confronting the high rates of diabetes, hypertension and inflammation in China.
中国是全球糖尿病患病率最高的国家，糖尿病、高血压和炎症的患病率持续上升，在儿童中尤为明显。目前对于这些心血管代谢危险因素在父母与子女之间的关联强度知之甚少；因此，基于家庭的降低风险策略的潜力尚不清楚。
本研究旨在在中国一个地域广泛的大样本中，探讨血红蛋白A1c（HbA1c）、血压（BP）和C反应蛋白（CRP）的亲子关联。
在参与2009年中国健康与营养调查的940对亲子（子女年龄在7至17岁之间）中，我们通过空腹血测量了每个人的HbA1c和CRP，并测量了血压。我们使用性别特异性随机效应线性回归来研究这些危险因素的亲子关联，并考虑了家庭内部的聚类情况。
儿童的HbA1c与父母的HbA1c呈正相关。β系数范围从父女对的0.06（95%CI 0.03 - 0.12）到母子对的0.43（95%CI 0.28 - 0.58）。我们还检测到母女之间血压呈正相关，以及父子之间CRP呈正相关。
中国家庭中HbA1c、BP和CRP存在具有统计学意义的亲子关联，这表明基于家庭的干预措施可能有助于应对中国糖尿病、高血压和炎症的高发病率。
