Wejryd Erik, Marchini Giovanna, Bang Peter, Jonsson Baldvin, Ådén Ulrika, Abrahamsson Thomas
Division of Children's and Women's Health, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Department of Paediatrics, Vrinnevi Hospital, Norrköping, Sweden.
Acta Paediatr. 2025 Aug;114(8):1817-1824. doi: 10.1111/apa.70030. Epub 2025 Feb 13.
To assess neurodevelopment and growth at 2 years corrected age in children born extremely preterm, supplemented with Limosilactobacillus reuteri or placebo.
Design: Secondary analysis of register data after randomised double-blind placebo-controlled trial.
Inclusion at two neonatal intensive care units in Sweden. Local follow-up per national guidelines.
134 infants born at 23-27 weeks' gestation with a birth weight < 1000 g.
Daily enteral supplementation with placebo or Limosilactobacillus reuteri DSM 17938 (2.5 × 10 colony forming units), from within 72 h after birth to postmenstrual week 35-36.
Bayley-III developmental assessment and auxology at 24 ± 3 months corrected age.
Follow-up data were available for 110 of 117 surviving participants, and 85 children were assessed with Bayley-III. Mean language score after supplementation with L. reuteri was 90 (95% confidence interval: 85-95) compared to 83 in the placebo group (95% CI: 78-88), p = 0.04. No other significant differences in neurodevelopment or growth were observed.
Supplementation with L. reuteri in extremely preterm infants was not associated with altered growth nor general neurodevelopmental outcomes at 2 years while language index was improved. This is interesting given previously reported early improved growth of head circumference.
评估出生时极早产且补充了罗伊氏乳杆菌或安慰剂的儿童在矫正年龄2岁时的神经发育和生长情况。
设计：随机双盲安慰剂对照试验后登记数据的二次分析。
纳入瑞典的两个新生儿重症监护病房。按照国家指南进行本地随访。
134例妊娠23 - 27周、出生体重<1000克的婴儿。
从出生后72小时内至月经后第35 - 36周，每天经肠补充安慰剂或罗伊氏乳杆菌DSM 17938（2.5×10菌落形成单位）。
在矫正年龄24±3个月时进行贝利婴幼儿发展量表第三版（Bayley - III）发育评估和人体测量学评估。
117名存活参与者中有110名有随访数据，85名儿童接受了贝利婴幼儿发展量表第三版评估。补充罗伊氏乳杆菌后的平均语言得分是90（95%置信区间：85 - 95），而安慰剂组为83（95%置信区间：78 - 88），p = 0.04。在神经发育或生长方面未观察到其他显著差异。
极早产婴儿补充罗伊氏乳杆菌在2岁时与生长改变或一般神经发育结局无关，但语言指数有所改善。鉴于先前报道的头围早期生长改善，这一结果很有意思。
