Bresnick E
Drug Metab Rev. 1979;10(2):209-23. doi: 10.3109/03602537908997469.
In this report the ability of nuclei to carry out mixed function oxidase activity has been discussed. The properties of the nuclear system have been contrasted with those of microsomes and the localization of the nuclear mixed function oxidase has been definitively established. In addition, the nuclei have been shown to contain an inducible O-deethylase and epoxide hydrase(s). Finally, nuclei have been demonstrated to catalyze the formation of benzo[a]pyrene syn- and anti-diolepoxides, ultimate carcinogenic forms of this polycyclic hydrocarbon.
在本报告中，已讨论了细胞核进行混合功能氧化酶活性的能力。已将核系统的特性与微粒体的特性进行了对比，并明确确定了核混合功能氧化酶的定位。此外，已证明细胞核含有一种可诱导的O-脱乙基酶和环氧化物水解酶。最后，已证实细胞核可催化苯并[a]芘顺式和反式二环氧物的形成，这是这种多环烃的最终致癌形式。
