微粒体和核膜在苯并(a)芘代谢活化导致与核大分子结合中的作用。 - Suppr | 超能文献

The role of microsomes and nuclear envelope in the metabolic activation of benzo(a)pyrene leading to binding with nuclear macromolecules.

作者信息

Pezzuto J M, Lea M A, Yang C S

出版信息

Cancer Res. 1977 Sep;37(9):3427-33.

Abstract

摘要

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The role of microsomes and nuclear envelope in the metabolic activation of benzo(a)pyrene leading to binding with nuclear macromolecules.微粒体和核膜在苯并(a)芘代谢活化导致与核大分子结合中的作用。

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Modulation of the binding of the carcinogen benzo(a)pyrene to rat liver DNA in vivo by selective induction of microsomal and nuclear aryl hydrocarbon hydroxylase activity.通过选择性诱导微粒体和细胞核芳烃羟化酶活性对致癌物苯并(a)芘在体内与大鼠肝脏DNA结合的调节作用。

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Influence of inducers and inhibitors of mixed-function oxidasts on benzo(a)pyrene binding to the DNA of rat liver nuclei.混合功能氧化酶诱导剂和抑制剂对苯并(a)芘与大鼠肝细胞核DNA结合的影响。

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Nuclear uptake and subsequent nuclear metabolism of benzo(a)pyrene complexed to cytosolic proteins.与胞质蛋白结合的苯并(a)芘的核摄取及随后的核代谢。

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Characteristics of benzo(a)pyrene metabolism and cytochrome P-450 heterogeneity in rat liver nuclear envelope and comparison to microsomal membrane.大鼠肝细胞核膜中苯并(a)芘代谢及细胞色素P-450异质性的特征及其与微粒体膜的比较。

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Formation in isolated rat liver microsomes and nuclei of benzo(a)pyrene metabolites that bind to DNA.在分离的大鼠肝微粒体和细胞核中形成与DNA结合的苯并(a)芘代谢产物。

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Inhibition of benzo(a)pyrene and benzo(a)pyrene 7,8-dihydrodiol metabolism by benzo(a)pyrene quinones.苯并(a)芘醌对苯并(a)芘和苯并(a)芘7,8-二氢二醇代谢的抑制作用。

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引用本文的文献

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Effect of selected induction of microsomal and nuclear aryl hydrocarbon monooxygenase and epoxide hydrolase as well as cytoplasmic glutathione S-epoxide transferase on the covalent binding of the carcinogen benzo(a)pyrene to rat liver DNA in vivo.微粒体和细胞核芳烃单加氧酶、环氧化物水解酶以及细胞质谷胱甘肽S-环氧化物转移酶的特定诱导对致癌物苯并(a)芘在体内与大鼠肝脏DNA共价结合的影响。

J Cancer Res Clin Oncol. 1980;98(2):139-52. doi: 10.1007/BF00405958.