Bishop Tammie, Ratcliffe Peter J
Physiology (Bethesda). 2025 Feb 13. doi: 10.1152/physiol.00043.2024.
More than 100 years after the original descriptions of altitude adaptation, it is now clear that many of these responses are mediated by a specific isoform of the transcription factor hypoxia-inducible factor (HIF-2α). Here, we review this work, including connectivity with the oxygen chemosensitive response itself, and with paraganglioma, a tumour often affecting chemosensitive tissues.
在最初描述海拔适应的100多年后，现在很清楚的是，其中许多反应是由转录因子缺氧诱导因子（HIF-2α）的一种特定亚型介导的。在此，我们回顾这项工作，包括与氧化学感受性反应本身以及与副神经节瘤（一种常影响化学感受性组织的肿瘤）的联系。
