Lee Seok Joon, Kim Young Sam, Jeong Hyung Hwa, Kim Tae Hyung, Choi Jong Woo
From the Department of Plastic and Reconstructive Surgery, Asan Medical Center, University of Ulsan College of Medicine.
Department of Plastic and Reconstructive Surgery, Soonchunhyang University Bucheon Hospital.
Plast Reconstr Surg. 2025 Aug 1;156(2):208e-214e. doi: 10.1097/PRS.0000000000012026. Epub 2025 Feb 7.
Ultrafine dicing, which reduces cartilage particles to less than 0.2 mm, has gained attention for producing dense implants with reduced distortion. However, concerns about long-term viability and cell damage because of extensive manipulation remain. The authors aimed to compare the histologic outcomes of ultrafine and conventionally diced cartilage wrapped in fascia in a rabbit model, providing insight into their potential use in rhinoplasty.
Ten New Zealand White rabbits were divided into 2 groups. Cartilage was harvested from both ears, with 1 graft diced into 1- to 2-mm pieces and the other into pieces smaller than 0.2 mm. Both types were wrapped in fascia and implanted subcutaneously. Histologic analyses, using hematoxylin and eosin, Masson trichrome, and safranin-O staining, were performed at 8 weeks and 6 months postoperatively. The percentages of cartilage cells and dead space were compared between groups.
There was significantly higher cartilage cell density in the ultrafine diced group at both 8 weeks and 6 months than in the conventionally diced group. The ultrafine diced cartilage also exhibited less dead space and maintained a dense composition of type II collagen, suggesting a resilient and natural implant material.
Ultrafine dicing resulted in superior histologic outcomes, with higher cartilage cell density and less fibrosis compared with conventional methods. These findings suggest that ultrafine diced cartilage may be an effective method for achieving natural and stable results in rhinoplasty. Further research involving human participants is needed to confirm these results.
Ultrafine dicing of cartilage provides superior histological outcomes, with higher cell density and less fibrosis compared with conventional methods. This technique may offer plastic surgeons a more effective option for achieving stable, natural results in rhinoplasty, pending further human studies.
超微切碎技术可将软骨颗粒减小至小于0.2毫米，因其能制造出变形较小的致密植入物而受到关注。然而，由于操作广泛，对其长期生存能力和细胞损伤的担忧依然存在。作者旨在比较在兔模型中，包裹在筋膜中的超微切碎软骨和传统切碎软骨的组织学结果，以深入了解它们在鼻整形术中的潜在用途。
将10只新西兰白兔分为2组。从双耳采集软骨，一组移植物切成1至2毫米的碎片，另一组切成小于0.2毫米的碎片。两种类型的软骨均包裹在筋膜中并皮下植入。术后8周和6个月进行苏木精-伊红染色、Masson三色染色和番红O染色的组织学分析。比较两组之间软骨细胞的百分比和死腔情况。
在术后8周和6个月时，超微切碎组的软骨细胞密度均显著高于传统切碎组。超微切碎的软骨死腔也更少，并保持了II型胶原的致密组成，表明其是一种有弹性的天然植入材料。
与传统方法相比，超微切碎产生了更好的组织学结果，软骨细胞密度更高，纤维化更少。这些发现表明，超微切碎软骨可能是在鼻整形术中获得自然和稳定效果的有效方法。需要进一步开展涉及人类受试者的研究来证实这些结果。
与传统方法相比，软骨的超微切碎提供了更好的组织学结果，细胞密度更高，纤维化更少。在进一步的人体研究之前，这项技术可能为整形外科医生在鼻整形术中实现稳定、自然的效果提供更有效的选择。
