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髓源性抑制细胞的招募与免疫抑制机制及其对骨转移性癌症的影响

The Recruitment and Immune Suppression Mechanisms of Myeloid-Derived Suppressor Cells and Their Impact on Bone Metastatic Cancer.

作者信息

Li Chengyuan, Xue Yucheng, Yinwang Eloy, Ye Zhaoming

机构信息

Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Orthopedics Research Institute of Zhejiang University, Hangzhou, China.

出版信息

Cancer Rep (Hoboken). 2025 Feb;8(2):e70044. doi: 10.1002/cnr2.70044.

DOI:10.1002/cnr2.70044
PMID:39947253
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11825175/
Abstract

BACKGROUND

MDSCs are immature neutrophils and monocytes with immunosuppressive potentials, involving mononuclear MDSCs (M-MDSCs) and polymorphonuclear MDSCs (PMN-MDSCs).

RECENT FINDINGS

They are significant components of the tumor microenvironment (TME). Besides, recent studies also verified that MDSCs also facilitated the progression of bone metastasis by regulating the network of cytokines and the function of immune cells.

CONCLUSION

It is necessary to summarize the mechanisms of MDSC recruitment and immunosuppression, and their impact on bone metastasis.

摘要

背景

髓源性抑制细胞（MDSCs）是具有免疫抑制潜能的未成熟中性粒细胞和单核细胞，包括单核细胞源性MDSCs（M-MDSCs）和多形核MDSCs（PMN-MDSCs）。

最新发现

它们是肿瘤微环境（TME）的重要组成部分。此外，最近的研究还证实，MDSCs还通过调节细胞因子网络和免疫细胞功能促进骨转移的进展。

结论

有必要总结MDSC募集和免疫抑制的机制及其对骨转移的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576b/11825175/2f892442e642/CNR2-8-e70044-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576b/11825175/dff464e133f1/CNR2-8-e70044-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576b/11825175/f9d3da675c87/CNR2-8-e70044-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576b/11825175/2f892442e642/CNR2-8-e70044-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576b/11825175/dff464e133f1/CNR2-8-e70044-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576b/11825175/f9d3da675c87/CNR2-8-e70044-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576b/11825175/2f892442e642/CNR2-8-e70044-g003.jpg

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本文引用的文献

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SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches.SCUBE2 通过调节免疫抑制性成骨细胞龛促进腔型乳腺癌的骨转移。
Cell Res. 2023 Jun;33(6):464-478. doi: 10.1038/s41422-023-00810-6. Epub 2023 May 4.
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Meso-Hannokinol inhibits breast cancer bone metastasis via the ROS/JNK/ZEB1 axis.介汉可宁通过 ROS/JNK/ZEB1 轴抑制乳腺癌骨转移。
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Tumor-derived OBP2A promotes prostate cancer castration resistance.
肿瘤来源的 OBP2A 促进前列腺癌去势抵抗。
J Exp Med. 2023 Mar 6;220(3). doi: 10.1084/jem.20211546. Epub 2022 Dec 22.
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Oxaliplatin-Resistant Hepatocellular Carcinoma Drives Immune Evasion Through PD-L1 Up-Regulation and PMN-Singular Recruitment.奥沙利铂耐药肝细胞癌通过 PD-L1 上调和PMN 募集驱动免疫逃逸。
Cell Mol Gastroenterol Hepatol. 2023;15(3):573-591. doi: 10.1016/j.jcmgh.2022.12.002. Epub 2022 Dec 10.
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Toll-like receptor-targeted anti-tumor therapies: Advances and challenges. Toll 样受体靶向抗肿瘤治疗：进展与挑战。
Front Immunol. 2022 Nov 21;13:1049340. doi: 10.3389/fimmu.2022.1049340. eCollection 2022.
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The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells.基于树突状细胞的疫苗在肿瘤微环境中的作用：对髓系来源的抑制细胞的影响。
Front Immunol. 2022 Nov 15;13:1050484. doi: 10.3389/fimmu.2022.1050484. eCollection 2022.
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Tumor-Derived Exosomes and Their Role in Breast Cancer Metastasis.肿瘤衍生外泌体及其在乳腺癌转移中的作用。
Int J Mol Sci. 2022 Nov 13;23(22):13993. doi: 10.3390/ijms232213993.
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