Pereira Irislene Costa, Pedrosa-Santos Álina Mara Carvalho, Martins Jorddam Almondes, Sousa Athanara Alves de, Nobre Taline Alves, Torres Lucillia Rabelo de Oliveira, Silva Felipe Cavalcanti Carneiro da, Severo Juliana Soares, Sousa João Marcelo de Castro E, Torres-Leal Francisco Leonardo
Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Department of Biophysics and Physiology, Laboratory of Metabolic Diseases Glauto Tuquarre (LabGT), Center for Health Sciences, Federal University of Piaui, Teresina, Piauí, Brazil; Center for Open and Distance Education (CEAD), Federal University of Piaui, Teresina, Piauí, Brazil.
Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Clin Nutr ESPEN. 2025 Apr;66:437-445. doi: 10.1016/j.clnesp.2025.02.001. Epub 2025 Feb 11.
Liver diseases pose a significant challenge to the well-being of the public, given their high prevalence and the potential to escalate to liver failure and hepatocellular carcinoma. The efficacy of current therapies is rather limited, resulting in the manifestation of severe side effects. Bromelain, derived from the pineapple plant, exhibits promising prospects for the treatment of inflammatory disorders, cancer, and wound healing, although its impact on liver functionality remains largely unexplored.
To evaluate the efficiency of bromelain in liver injuries, we performed a systematic review of preclinical studies.
Our search was conducted in August 2020 on PubMed and Scopus, employing the search terms "Liver disease," "Liver injury," and "Bromelain," with subsequent updates in December 2023.
Out of the 329 articles that were examined, only 7 fulfilled the criteria for inclusion.
Our research suggests that bromelain possesses both prophylactic and curative qualities in terms of liver damage, as supported by its ability to decrease enzyme levels, enhance liver structure, reduce oxidative stress markers, and regulate lipid metabolism. In summary, bromelain demonstrates a capacity to enhance liver function across a range of injury types.
鉴于肝脏疾病的高患病率以及其发展为肝衰竭和肝细胞癌的可能性，肝脏疾病对公众健康构成了重大挑战。目前疗法的疗效相当有限，还会引发严重的副作用。菠萝蛋白酶源自菠萝植物，在治疗炎症性疾病、癌症和伤口愈合方面展现出了良好的前景，尽管其对肝脏功能的影响在很大程度上仍未得到探索。
为了评估菠萝蛋白酶对肝损伤的疗效，我们对临床前研究进行了系统综述。
我们于2020年8月在PubMed和Scopus上进行搜索，使用了“肝脏疾病”“肝损伤”和“菠萝蛋白酶”等搜索词，并于2023年12月进行了后续更新。
在审查的329篇文章中，只有7篇符合纳入标准。
我们的研究表明，菠萝蛋白酶在肝损伤方面具有预防和治疗作用，这体现在它能够降低酶水平、改善肝脏结构、减少氧化应激标志物以及调节脂质代谢。总之，菠萝蛋白酶在一系列损伤类型中均表现出增强肝功能的能力。
