Lambrakis Kristina, Khan Ehsan, Liao Zhibin, Gerlach Joey, Nelson Adam J, Goodman Shaun G, Briffa Tom, Cullen Louise, Verjans Johan, Chew Derek P
College of Medicine and Public Health, Flinders University of South Australia, Adelaide, SA, Australia; Victorian Heart Institute, Monash University, Melbourne, Vic, Australia; MonashHeart, Monash Health, Melbourne, Vic, Australia.
College of Medicine and Public Health, Flinders University of South Australia, Adelaide, SA, Australia; South Australian Department of Health, Adelaide, SA, Australia.
Heart Lung Circ. 2025 May;34(5):497-505. doi: 10.1016/j.hlc.2024.11.023. Epub 2025 Feb 13.
With widespread adoption of high-sensitivity troponin assays, more individuals with myocardial injury are now identified, with type 1 myocardial infarction (T1MI) being less common despite having the most well-established evidence base to inform care. This study assesses the temporal time course of cardiovascular events among various forms of myocardial injury.
Consecutive hospital encounters were identified. Using the first episode of care during the sampling period, myocardial injury classifications (i.e., T1MI, acute injury/type 2 myocardial infarction [T2MI], chronic injury, and no injury) were established via two machine learning algorithms. The temporal time course of increased hazard for mortality, recurrent myocardial infarction, heart failure, and arrhythmia over 3 years were explored.
There were 176,787 index episodes; 6.9% were classified as T1MI, 6.0% as acute injury/T2MI, and 26.7% as chronic injury. Although each classification was associated with an early increased risk of all-cause mortality compared with no injury (incidence rate ratio [IRR]<30 days: T1MI: 19.97 [95% confidence interval 12.50-32.69]; acute injury/T2MI: 26.51 [16.80-42.97]; chronic injury: 15.37 [10.22-23.95]), the instantaneous relative hazard for recurrent myocardial infarction was highest in those with initial T1MI (IRR<30 days: T1MI: 28.81 [22.75-36.76]; acute injury/T2MI: 10.23 [7.60-13.77]; chronic injury:5.54 [4.34-7.41]). In contrast, the instantaneous hazard for heart failure in those with initial acute injury/T2MI and chronic injury remained increased over long-term follow up unlike in T1MI (IRR1 3 yrs: T1MI: 5.52 [4.99-6.09]; acute injury/T2MI: 10.36 [9.51-11.30]; chronic injury:7.40 [6.90-7.94]).
The substantial and persistent rate of late cardiac events highlights the need to establish an evidence base for the therapeutic management of "non-T1MI" diagnostic classifications and suggests opportunity to improve late outcomes using existing and emerging therapies.
