Melinda Mahabee-Gittens E, Matt Georg E, Lopez-Galvez Nicolas, Hoh Eunha, Quintana Penelope J E, Dodder Nathan G, Jandarov Roman A, Stone Lara, Wullenweber Chase A, Ahluwalia Jasjit S, Merianos Ashley L
Divison of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Pediatr Res. 2025 Feb 13. doi: 10.1038/s41390-025-03915-3.
Thirdhand smoke (THS) pollution is the residue of secondhand smoke (SHS) remaining in homes long after active smoking has ceased. This study is the first to characterize the clinical correlates of THS exposure (THSe) in children independent of secondhand smoke exposure (SHSe). The prevalence, sociodemographic characteristics, tobacco smoke exposure patterns, sources, clinical, and biomarker effects associated with THSe will be examined.
Smoking and nonsmoking parents and their 0-11-year-olds (N = 1013) were recruited. Children were categorized into tobacco smoke exposure (TSE) groups via biochemical validation with salivary cotinine and hand nicotine: (1) no exposure group (NEG); (2) THSe-only group (TEG); and (3) Mixed SHSe and THSe group (MEG). At enrollment, 6-weeks, and 6-months, parental assessments and children's biological and home samples were obtained and analyzed for SHSe, THSe, THS pollution, inflammatory and oxidative stress markers.
The mean (SD) child age was 5.8 (3.4) years; 50.7% were female; and 97% were non-Hispanic (97.0%); 67.5% were White, 25.7% were Black, 6.8% were Other/unknown race. In total, 57.9%, 18.2%, and 21.9% were classified in the NEG, TEG, and MEG, respectively. Sample and data analyses are ongoing.
This project will provide unique insights into how THSe in the absence of SHSe affects the clinical, inflammatory, and oxidative responses in children.
This is the first prospective longitudinal study to examine the prevalence of thirdhand smoke exposure in children of nonsmokers. Unlike prior tobacco smoke exposure research, this study will examine the contribution of thirdhand smoke exposure to pediatric health outcomes. Results will provide unique insights into how thirdhand smoke exposure in the absence of secondhand smoke exposure affects the clinical, inflammatory, and oxidative responses in children of nonsmokers.
三手烟（THS）污染是主动吸烟停止很久后残留在家庭中的二手烟（SHS）残留物。本研究首次独立于二手烟暴露（SHSe）来描述儿童三手烟暴露（THSe）的临床相关因素。将对与THSe相关的患病率、社会人口学特征、烟草烟雾暴露模式、来源、临床及生物标志物效应进行研究。
招募吸烟和不吸烟的父母及其0至11岁的孩子（N = 1013）。通过唾液可替宁和手部尼古丁进行生化验证，将儿童分为烟草烟雾暴露（TSE）组：（1）无暴露组（NEG）；（2）仅三手烟暴露组（TEG）；（3）二手烟和三手烟混合暴露组（MEG）。在入组时、6周和6个月时，获取父母评估以及儿童的生物样本和家庭样本，并分析SHSe、THSe、THS污染、炎症和氧化应激标志物。
儿童的平均（标准差）年龄为5.8（3.4）岁；50.7%为女性；97%为非西班牙裔（97.0%）；67.5%为白人，25.7%为黑人，6.8%为其他/种族不明。总计，分别有57.9%、18.2%和21.9%被归类到NEG、TEG和MEG组。样本和数据分析正在进行中。
本项目将为在无SHSe情况下THSe如何影响儿童的临床、炎症和氧化反应提供独特见解。
这是第一项前瞻性纵向研究，旨在调查非吸烟者子女中三手烟暴露的患病率。与先前的烟草烟雾暴露研究不同，本研究将考察三手烟暴露对儿童健康结果的影响。研究结果将为在无二手烟暴露情况下三手烟暴露如何影响非吸烟者子女的临床、炎症和氧化反应提供独特见解。
