Vutla Adilakshmi, Saxena Deepanshi, Maitra Rahul, Chopra Sidharth, Batra Sanjay
Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Lucknow, 226031, Uttar Pradesh, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
ChemMedChem. 2025 May 5;20(9):e202400955. doi: 10.1002/cmdc.202400955. Epub 2025 Feb 25.
The drastic increase in the emergence of methicillin and vancomycin resistant S. aureus has resulted in almost negligible treatment options available to tackle these drug-resistant strains and therefore, search for newer antibiotics is essential. In this context, a new series of quaternized fused β-carbolines was synthesized and evaluated for its anti-bacterial potential. Several compounds from the series displayed potent anti-bacterial activity against Gram-positive bacteria including the drug-resistant strains with minimal cytotoxicity and promising bactericidal action.
耐甲氧西林和万古霉素金黄色葡萄球菌的出现急剧增加，导致应对这些耐药菌株的治疗选择几乎微乎其微，因此，寻找新型抗生素至关重要。在此背景下，合成了一系列新型季铵化稠合β-咔啉，并对其抗菌潜力进行了评估。该系列中的几种化合物对革兰氏阳性菌，包括耐药菌株，显示出强效抗菌活性，细胞毒性极小且具有良好的杀菌作用。
