Kahan Riley, Enthoven Luke, Garoosi Kassra, Higinbotham Sean, Pflug Emily M, Lauder Alexander
University of Colorado School of Medicine, Aurora, USA.
Denver Health Medical Center, CO, USA.
Hand (N Y). 2025 Feb 13:15589447251317226. doi: 10.1177/15589447251317226.
Trigger finger (TF) causes pain and functional impairment. Previous studies have associated TF with carpal tunnel syndrome, which has been linked to obesity. This study investigated the relationship between obesity and the prevalence of TF.
A retrospective analysis was conducted using data from the TriNetX Research Network (2006-2024). Patients with risk factors for TF (rheumatoid arthritis, gout, amyloidosis, prior carpal tunnel release, spontaneous rupture of flexor tendons, hypothyroidism, Dupuytren disease, and diabetes mellitus) were excluded. Two cohorts were compared: (1) patients diagnosed with TF; and (2) those without. The groups underwent propensity score matching based on demographic attributes using a 1:1 nearest neighbor approach. Each patient's mean body mass index (BMI) was calculated by averaging all BMI measurements. Obesity was defined as a mean BMI greater than or equal to 30 kg/m. Multiple linear regression and logistic regression, incorporating TF diagnosis, BMI, and matched covariates, were used to adjust for confounding factors and estimate risk and odds ratios.
Data from 198 804 patients (99 402 per group) were analyzed. The prevalence of TF was positively associated with increasing BMI. Multiple linear regression revealed that BMI accounted for a small portion of the variance in TF prevalence. Logistic regression demonstrated an adjusted risk ratio of 1.02 (95% CI = [1.01, 1.03]) and an odds ratio of 1.03 (95% CI = [1.01, 1.05]), indicating a 2% to 3% increased risk of TF in obese patients.
Obesity was independently associated with TF. Obese patients had a 2% increased risk of TF compared with nonobese patients.
扳机指（TF）会导致疼痛和功能障碍。既往研究已将扳机指与腕管综合征相关联，而腕管综合征又与肥胖有关。本研究调查了肥胖与扳机指患病率之间的关系。
使用TriNetX研究网络（2006 - 2024年）的数据进行回顾性分析。排除具有扳机指危险因素（类风湿性关节炎、痛风、淀粉样变性、既往腕管松解术、屈肌腱自发性断裂、甲状腺功能减退、杜普伊特伦病和糖尿病）的患者。比较了两个队列：（1）诊断为扳机指的患者；（2）未患扳机指的患者。采用1:1最近邻法根据人口统计学特征对两组进行倾向得分匹配。通过对所有体重指数（BMI）测量值求平均来计算每位患者的平均BMI。肥胖定义为平均BMI大于或等于30kg/m²。使用纳入扳机指诊断、BMI和匹配协变量的多重线性回归和逻辑回归来调整混杂因素并估计风险比和优势比。
分析了198804例患者的数据（每组99402例）。扳机指的患病率与BMI升高呈正相关。多重线性回归显示，BMI在扳机指患病率的方差中占一小部分。逻辑回归显示调整后的风险比为1.02（95%CI = [1.01, 1.03]），优势比为1.03（95%CI = [1.01, 1.05]），表明肥胖患者患扳机指的风险增加2%至3%。
肥胖与扳机指独立相关。与非肥胖患者相比，肥胖患者患扳机指的风险增加2%。
