连接肥胖与肌腱病的炎症机制。
Inflammatory mechanisms linking obesity and tendinopathy.
作者信息
Lui Pauline Po Yee, Yung Patrick Shu Hang
机构信息
Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China.
出版信息
J Orthop Translat. 2021 Dec 9;31:80-90. doi: 10.1016/j.jot.2021.10.003. eCollection 2021 Nov.
UNLABELLED
Chronic tendinopathy is a debilitating tendon disorder with disappointing treatment outcomes. This review focuses on the potential roles of chronic low-grade inflammation in promoting tendinopathy in obesity. A systematic literature search was performed to identify all clinical studies supporting the actions of obesity-associated inflammatory mediators in the development of tendinopathy. The mechanisms of obesity-induced chronic inflammation in adipose tissue are firstly reviewed. Common inflammatory mediators potentially linking obesity and the development of tendinopathy, and their association with mechanical overuse, are discussed, along with pre-clinical evidences and a systematic literature search on clinical studies. The potential contribution of local adipose tissues in the promotion of inflammation, pain and tendon degeneration is then discussed. The future research directions are proposed.
TRANSLATIONAL POTENTIAL STATEMENT
Better understanding of the roles of obesity-associated inflammatory mediators on tendons will clarify the pathophysiological drivers of tendinopathy in patients with obesity and identify possible treatment targets. Further studies on the mechanisms of obesity-induced chronic inflammation on tendon are a promising direction for the treatment of tendinopathy.
未标注
慢性肌腱病是一种使人衰弱的肌腱疾病，治疗效果令人失望。本综述重点关注慢性低度炎症在肥胖人群肌腱病发病过程中的潜在作用。进行了系统的文献检索，以确定所有支持肥胖相关炎症介质在肌腱病发展中作用的临床研究。首先回顾了肥胖诱导的脂肪组织慢性炎症的机制。讨论了可能将肥胖与肌腱病发展联系起来的常见炎症介质，以及它们与机械性过度使用的关联，同时介绍了临床前证据和关于临床研究的系统文献检索情况。接着探讨了局部脂肪组织在促进炎症、疼痛和肌腱退变方面的潜在作用。最后提出了未来的研究方向。
转化潜力声明
更好地理解肥胖相关炎症介质在肌腱上的作用，将阐明肥胖患者肌腱病的病理生理驱动因素，并确定可能的治疗靶点。进一步研究肥胖诱导的肌腱慢性炎症机制是治疗肌腱病的一个有前景的方向。
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