当代通用超声心动图软件测定健康受试者左心室整体纵向应变的参考范围
Reference Ranges of Left Ventricular Global Longitudinal Strain by Contemporary Vendor-Neutral Echocardiography Software in Healthy Subjects.
作者信息
Arockiam Aro Daniela, Dong Tiffany, Agrawal Ankit, Dahdah Joseph El, Haroun Elio, Majid Muhammad, Sorathia Sharmeen, Grimm Richard A, Collier Patrick, Rodriguez Leonardo, Popovic Zoran B, Griffin Brian P, Wang Tom Kai Ming
机构信息
Section of Cardiovascular Imaging, Department of Cardiovascular Medicine, Sydell and Arnold Miller Heart, Vascular, and Thoracic Institute, Cleveland, Ohio, USA.
出版信息
Echocardiography. 2025 Feb;42(2):e70102. doi: 10.1111/echo.70102.
BACKGROUND
Left ventricular global longitudinal strain (LVGLS) by speckle-tracking transthoracic echocardiography (TTE) is an established measure of left ventricular systolic function with many clinical applications. Strain software has evolved to achieve vendor-neutrality in recent developments, although there is a notable absence of external validation studies. We assessed the normal ranges and associated factors of two-dimensional LVGLS quantification by TomTec, EchoPAC, VVI, and Epsilon contemporary strain software in a healthy cross-sectional cohort.
METHODS
One hundred healthy subjects undergoing TTE during January-April 2023 at our institution were cross-sectionally recruited, 20 per age-group, 50% were female, and 50% had GE and 50% Philips scans. TomTec version 51.02 (Autostrain LV), EchoPAC version 206 (AFI-LV), VVI version (V.2.00-070730), and Epsilon (5.0.2.11295) were utilized to quantify two-dimensional LVGLS in all patients for comparative and regression analyses.
RESULTS
Means and lower limits of normal (95% confidence intervals) of LVGLS were -17.1% (-17.5%, -16.7%) and -14.7% (-15.4%, -14.0%) for TomTec; -17.8% (-18.4%, -17.2%) and -14.4% (-15.3%, -13.5%) for EchoPAC; -16.3% (-16.9%, -15.7%) and -13.0% (-13.9%, -12.1%) for VVI; and -17.0% (-17.6%, -16.4%) and -12.8% (-13.8%, -11.8%) for Epsilon. Factors significantly associated with LVGLS measurements in multivariable regression analyses with their beta-coefficients (95% CI) were female -1.36 (-2.12, -0.59), heart rate (per 10 bpm) with a coefficient of 0.38 (0.10-0.66), left ventricular ejection fraction (per 10%) -1.03 (-1.72, -0.34), and EchoPAC (vs. TomTec) -0.62 (-1.2, 0.0), VVI (vs. TomTec) 0.82 (0.23, 1.41) and Epsilon (vs. TomTec) 0.13 (-0.45, 0.72).
CONCLUSION
LVGLS measurements were feasible across all four strain software on both GE and Philips scans in this study. Reference ranges to define normal, abnormal, and borderline LVGLS values along with associated factors in healthy patients are reported to enable clinical applications.
背景
经胸超声心动图斑点追踪技术（TTE）测量的左心室整体纵向应变（LVGLS）是评估左心室收缩功能的一项成熟指标，具有多种临床应用。尽管在最近的发展中，应变软件已发展到实现供应商中立，但仍明显缺乏外部验证研究。我们在一个健康横断面队列中评估了TomTec、EchoPAC、VVI和Epsilon当代应变软件对二维LVGLS定量的正常范围及相关因素。
方法
2023年1月至4月期间，在我们机构接受TTE检查的100名健康受试者被纳入横断面研究，每个年龄组20人，50%为女性，50%接受GE扫描，50%接受飞利浦扫描。使用TomTec 51.02版本（Autostrain LV）、EchoPAC 206版本（AFI-LV）、VVI版本（V.2.00 - 070730）和Epsilon（5.0.2.11295）对所有患者的二维LVGLS进行定量，以进行比较和回归分析。
结果
TomTec测量的LVGLS均值及正常下限（95%置信区间）分别为-17.1%（-17.5%，-16.7%）和-14.7%（-15.4%，-14.0%）；EchoPAC分别为-17.8%（-18.4%，-17.2%）和-14.4%（-15.3%，-13.5%）；VVI分别为-16.3%（-16.9%，-15.7%）和-13.0%（-13.9%，-12.1%）；Epsilon分别为-17.0%（-17.6%，-16.4%）和-12.8%（-13.8%，-11.8%）。在多变量回归分析中，与LVGLS测量值显著相关的因素及其β系数（95%置信区间）为：女性-1.36（-2.12，-0.59），心率（每10次心跳）系数为0.38（0.10 - 0.66），左心室射血分数（每10%）-1.03（-1.72，-0.34），以及EchoPAC（与TomTec相比）-0.62（-1.2，0.0），VVI（与TomTec相比）0.82（0.23，1.41），Epsilon（与TomTec相比）0.13（-0.45，0.72）。
结论
在本研究中，在GE和飞利浦扫描上，所有四种应变软件测量LVGLS均可行。报告了健康患者中定义正常、异常和临界LVGLS值的参考范围以及相关因素，以促进临床应用。
Zotero 插件