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在一只犬中使用变应原特异性免疫疗法成功治疗难治性中耳炎

Successful Management of Refractory Otitis Media Using Allergen-Specific Immunotherapy in a Dog.

作者信息

Kim Jihyun, Lee Ji-Hye, Kim Yeji, Song Yunji, Kim Ha-Jung

机构信息

Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, South Korea.

BK 21 Project Team, College of Veterinary Medicine, Chonnam National University, Gwangju, South Korea.

出版信息

Vet Med Sci. 2025 Mar;11(2):e70253. doi: 10.1002/vms3.70253.

Abstract

BACKGROUND

Allergen-specific immunotherapy (ASIT) is a highly effective treatment for atopic dermatitis. In humans, it has been reported to be significantly more effective than medication alone for the treatment of otitis media. ASIT can also be used in dogs, but it is not typically the first-line treatment for otitis externa and media.

OBJECTIVES

This case report describes the successful management of refractory otitis media in a dog with frequent abscess recurrence following total ear canal ablation (TECA) using ASIT.

METHODS

A 9-year-old spayed female American Cocker Spaniel presented with a head tilt and a recurrent abscess adjacent to the left TECA site. A dermatological examination revealed secondary pyoderma. In open-mouth view radiography and CT, fluid in the tympanic bullae and lysis of the tympanic bullae wall were observed. The TECA was repeated twice and anti-inflammatory medication was administered, but the lesions reappeared. As a fundamental treatment, ASIT was included in the therapy.

RESULTS

After ASIT, the symptoms did not reoccur, even though the use of prednisolone was gradually reduced and discontinued over a period of two months. Currently, only ASIT has demonstrated progress in managing the patient's condition, even a year after discontinuing other medications. The patient's symptoms have not recurred and are well managed.

CONCLUSIONS

A case of refractory otitis media, induced by atopic dermatitis, was effectively managed with ASIT over a prolonged period in a dog.

摘要

背景

变应原特异性免疫疗法(ASIT)是治疗特应性皮炎的一种高效疗法。在人类中,据报道其治疗中耳炎比单独使用药物显著更有效。ASIT也可用于犬类,但它通常不是外耳道炎和中耳炎的一线治疗方法。

目的

本病例报告描述了一只犬在全耳道切除术(TECA)后频繁脓肿复发的难治性中耳炎,使用ASIT成功治疗的情况。

方法

一只9岁已绝育的雌性美国可卡犬出现头部倾斜,且在左TECA部位附近有复发性脓肿。皮肤科检查发现继发性脓皮病。在开口位X线摄影和CT检查中,观察到鼓泡内有液体以及鼓泡壁溶解。TECA重复进行了两次,并给予了抗炎药物,但病变仍再次出现。作为基本治疗方法,ASIT被纳入治疗方案。

结果

在进行ASIT后,症状未再复发,尽管泼尼松龙在两个月的时间内逐渐减量并停用。目前,即使在停用其他药物一年后,仅ASIT在控制该患者病情方面取得了进展。患者的症状未再复发,病情得到良好控制。

结论

一只犬的由特应性皮炎引起的难治性中耳炎,通过ASIT在较长时间内得到了有效治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6399/11826327/13ad91ba0f8f/VMS3-11-e70253-g006.jpg

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