Friedman Matan, Jaffe Nadine, Tairy Daniel, Torem Maya, Raziel Arieh, Finkelstein Maya, Horowitz Eran, Weissman Ariel, Mizrachi Yossi
Reprod Fertil. 2025 Feb 27;6(1). doi: 10.1530/RAF-24-0118. Print 2025 Jan 1.
Planned oocyte cryopreservation (POC) has become widely available, allowing women to circumvent age-related fertility decline. The aim of our study was to examine whether women who have undergone POC were able to correctly predict the chance of having a child with their cryopreserved oocytes. We conducted a telephone survey with 260 women who underwent POC at our center between January 2017 and December 2023. Participants were asked to estimate their chance of having at least one live birth in case they would use their cryopreserved oocytes. For each participant, we also calculated the chance of achieving at least one live birth based on her age at the last oocyte retrieval and the number of cryopreserved oocytes, according to a model published by Goldman and colleagues in 2017. The median estimated probability of achieving a live birth was 50%, while the median calculated probability was 75% (P < 0.001). Only 28.1% of the participants accurately estimated their chances. In conclusion, a large percentage of women undergoing POC underestimate the probability of achieving a live birth if they use their cryopreserved oocytes. Improved counseling is essential to provide comprehensive information about the probability of live birth and prevent women from undergoing unnecessary treatments.
More and more women choose to freeze eggs in order to circumvent age-related fertility decline. In this study, we asked women to estimate their chance of having a child if they used their frozen eggs in the future. For each patient, the chance was also calculated based on a model taking into account the number of eggs she had frozen and her age during egg freezing. Surprisingly, women estimated their chance of having a child as being lower than it actually is. Our results highlight the importance of providing patients with clear information about treatment success to prevent them from undergoing unnecessary additional treatments.
计划性卵母细胞冷冻保存（POC）已广泛应用，使女性能够规避与年龄相关的生育能力下降。我们研究的目的是检查接受POC的女性是否能够正确预测使用其冷冻保存的卵母细胞生育孩子的几率。我们对2017年1月至2023年12月期间在我们中心接受POC的260名女性进行了电话调查。参与者被要求估计如果使用其冷冻保存的卵母细胞至少生育一个活产婴儿的几率。对于每位参与者，我们还根据她最后一次取卵时的年龄和冷冻保存的卵母细胞数量，按照戈德曼及其同事在2017年发表的模型计算了至少生育一个活产婴儿的几率。估计实现活产的概率中位数为50%，而计算得出的概率中位数为75%（P<0.001）。只有28.1%的参与者准确估计了她们的几率。总之，很大一部分接受POC的女性低估了使用其冷冻保存的卵母细胞实现活产的概率。改善咨询对于提供有关活产概率的全面信息以及防止女性接受不必要的治疗至关重要。
越来越多的女性选择冷冻卵子以规避与年龄相关的生育能力下降。在本研究中，我们要求女性估计如果她们将来使用冷冻卵子生育孩子的几率。对于每位患者，还根据一个考虑了她冷冻的卵子数量和卵子冷冻时年龄的模型计算了几率。令人惊讶的是，女性估计她们生育孩子的几率低于实际情况。我们的结果凸显了向患者提供有关治疗成功率的明确信息以防止她们接受不必要的额外治疗的重要性。
