CReATe Fertility Centre, Toronto, Canada.
CReATe Fertility Centre, Toronto, Canada.
Reprod Biomed Online. 2021 Feb;42(2):442-450. doi: 10.1016/j.rbmo.2020.10.004. Epub 2020 Oct 15.
To examine the motivations, life circumstances and parenthood aspirations of a cohort of women who underwent planned oocyte cryopreservation (POC) at a Canadian academic IVF centre.
A single-site, cross-sectional, anonymous quantitative study using a study-specific questionnaire administrated via SurveyMonkey®. Of the 224 women who completed at least one POC cycle between 2012 and 2018, 198 were reached by email and invited to participate.
Of the 98 (49.5%) questionnaires returned, 86 were fully completed and were analysed. Mean age at first POC cycle was 35.7 ± 2.4 (range 27-43) and at survey was 37.7 ± 2.5 years. At POC, 77% were single and 97.7% childless. At survey, 96% had not attempted to use their cryopreserved oocytes, yet 26 (30%) had tried natural conception or fertility treatments. Of these, three conceived naturally and two by assisted reproduction. Eighty-five per cent expressed a strong motherhood desire and 67.1% indicated that usage of their cryopreserved oocytes was mostly contingent on relationship status. Many expressed a desire for shared genetic parenthood within a committed relationship. Forty-seven per cent did not want to carry a pregnancy beyond the age of 46.
The findings of this study confirm the central role of age and relationship status in influencing women's POC decisions and oocyte utilization plans. The late age at POC could be explained by women using it toward the end of their peak reproductive years to leverage their remaining chances of genetic motherhood. Surveying women at later points following POC would help to gain a more comprehensive picture of their oocyte utilization and disposition plans.
调查在加拿大一家学术试管婴儿中心接受计划卵母细胞冷冻保存（POC）的女性队列的动机、生活状况和育儿愿望。
一项单站点、横断面、匿名定量研究，使用特定于研究的问卷，通过 SurveyMonkey® 进行管理。在 2012 年至 2018 年间完成至少一次 POC 周期的 224 名女性中，通过电子邮件联系了 198 名并邀请她们参加。
在返回的 98 份（49.5%）问卷中，有 86 份完整填写并进行了分析。第一次 POC 周期的平均年龄为 35.7±2.4（范围 27-43），调查时的年龄为 37.7±2.5 岁。在 POC 时，77%是单身，97.7%没有孩子。在调查时，96%的人尚未尝试使用其冷冻保存的卵母细胞，但 26 人（30%）尝试了自然受孕或生育治疗。其中，三人自然受孕，两人通过辅助生殖受孕。85%表达了强烈的母性愿望，67.1%表示使用冷冻保存的卵母细胞主要取决于关系状况。许多人表示希望在承诺的关系中拥有共同的遗传父母身份。47%的人不想在 46 岁以后怀孕。
本研究的结果证实了年龄和关系状况在影响女性 POC 决策和卵母细胞使用计划方面的核心作用。POC 的晚期年龄可能是由于女性在其生育高峰期的末期使用它，以利用她们剩余的遗传母亲身份的机会。在 POC 后更晚的时间点调查女性将有助于更全面地了解她们的卵母细胞使用和处置计划。
