Trindade C E, de Nóbrega F J, Sartor M E, Suguihara C Y, Tonete S S, Curi P R
Biol Neonate. 1985;47(4):211-6. doi: 10.1159/000242118.
We have studied the alkaline ribonuclease (RNase) activity in maternal serum and serum of full-term small- (T-SGA), full-term appropriate- (T-AGA) and preterm appropriate-for-gestational age (PT-AGA) newborns. A significantly lower level of RNase was observed in T-AGA and T-SGA newborns on the 30th day of age and in PT-AGA newborns on the 15th and 30th days of age, as compared to other T-AGA, T-SGA and PT-AGA groups of infants at birth. RNase activity was significantly higher in cord blood than in the maternal blood in all categories studied. Moreover, in preterm newborns, RNase activity in cord blood was significantly higher in those presenting a lower gestational age. We did not observe any significant difference in RNase levels in the cord blood of newborns from the 3 categories studied. The same results were observed concerning maternal blood. We, therefore, conclude that RNase activity in cord blood or in maternal blood is not a very satisfactory indicator of fetal malnutrition.
我们研究了足月小样儿（T-SGA）、足月适于胎龄儿（T-AGA）和早产适于胎龄儿（PT-AGA）新生儿的母亲血清以及这些新生儿血清中的碱性核糖核酸酶（RNase）活性。与出生时的其他T-AGA、T-SGA和PT-AGA组婴儿相比，在30日龄的T-AGA和T-SGA新生儿以及15日龄和30日龄的PT-AGA新生儿中观察到RNase水平显著降低。在所有研究类别中，脐带血中的RNase活性显著高于母亲血液中的RNase活性。此外，在早产新生儿中，胎龄较低的新生儿脐带血中的RNase活性显著更高。我们在所研究的3类新生儿的脐带血中未观察到RNase水平有任何显著差异。母亲血液的情况也是如此。因此，我们得出结论，脐带血或母亲血液中的RNase活性并不是胎儿营养不良的一个非常令人满意的指标。
