Aromolo Italo Francesco, Boggio Francesca Laura, Moltrasio Chiara, Pini Giuditta, Brevi Marco, Romagnuolo Maurizio, Maronese Carlo Alberto, Marzano Angelo Valerio
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Dermatology Unit, Milan University, Via Pace, 9, 20122, Milan, Italy.
Arch Dermatol Res. 2025 Feb 14;317(1):412. doi: 10.1007/s00403-025-03901-z.
Interleukin-13 (IL-13), a key T-helper 2 cytokine, has a central role in type 2 inflammation and is implicated in various skin disorders. This study investigated the IL-13 immunohistochemical expression in skin biopsies from patients with atopic dermatitis (AD), psoriasis vulgaris, morphea, Grover's disease, and immune checkpoint inhibitor-induced bullous pemphigoid (ICI-BP). AD biopsies showed the highest IL-13 expression (mean 27.4%), consistent with its established role in the pathogenesis. Psoriasis displayed moderate positivity (mean 8.62%), indicating IL-13's possible involvement in hybrid or phenotypic overlap forms. Minimal expression was detected in Grover's disease (1.8%) and ICI-BP (2.13%), while no positivity was observed in morphea. These findings highlight the diverse roles of IL-13 across skin disorders, with potential implications for targeted therapies.
白细胞介素-13（IL-13）是一种关键的辅助性T细胞2细胞因子，在2型炎症中起核心作用，并与多种皮肤疾病有关。本研究调查了特应性皮炎（AD）、寻常型银屑病、硬斑病、格罗弗病和免疫检查点抑制剂诱导的大疱性类天疱疮（ICI-BP）患者皮肤活检中IL-13的免疫组化表达。AD活检显示IL-13表达最高（平均27.4%），与其在发病机制中已确立的作用一致。银屑病表现为中度阳性（平均8.62%），表明IL-13可能参与混合型或表型重叠型。在格罗弗病（1.8%）和ICI-BP（2.13%）中检测到最低表达，而硬斑病中未观察到阳性。这些发现突出了IL-13在各种皮肤疾病中的不同作用，对靶向治疗具有潜在意义。
