Hieta Niina K, Tapana Lotta, Söderlund Jenni M, Huvila Jutta K, Talve Lauri A I, Haataja Marjut A M
Department of Dermatology.
Auria Clinical Informatics.
J Low Genit Tract Dis. 2025 Jul 1;29(3):288-292. doi: 10.1097/LGT.0000000000000879. Epub 2025 Feb 14.
Lichen planus (LP) is a chronic inflammatory skin disease that may affect the skin, scalp, nails, and mucosa. The aim of this study was to investigate the risk of genital premalignant and malignant conditions in patients with anogenital LP (agLP).
The authors identified 60 male and 56 female patients with agLP by searching the biobank archives for a genital or perianal skin biopsy showing LP between 2004 and 2020. They also included 10 randomly selected age- and sex-matched controls for each patient. The risks of genital cancers and their precursors were evaluated.
The incidence of agLP was 1.54 per 100,000 men and 1.36 per 100,000 women. There was no statistical difference between male and female incidence ( p = .5721). The odds ratio (OR) for high-grade squamous intraepithelial lesion (HSIL) of the vulva was 31.2 (95% CI = 2.46-1645.00; p = .01). The OR for penile neoplasias could not be calculated because control patients had no neoplasias, but the difference was suggestive of statistical significance (95% CI = 1.90-infinite; p = .008). The mean age at the time of diagnosis of agLP was 59.9 years (median 62 years) in female patients and 40.8 years (median 33 years) in male patients. The difference in the mean ages of female and male patients was statistically significant (95% CI = 11.92-26.13; p < .001).
Patients with agLP may have an increased risk for vulvar HSIL and penile neoplasia.
扁平苔藓（LP）是一种慢性炎症性皮肤病，可累及皮肤、头皮、指甲和黏膜。本研究旨在调查肛门生殖器扁平苔藓（agLP）患者发生生殖器癌前病变和恶性病变的风险。
作者通过检索生物样本库档案，找出2004年至2020年间有生殖器或肛周皮肤活检显示为LP的60例男性和56例女性agLP患者。他们还为每位患者随机选取了10名年龄和性别匹配的对照。评估了生殖器癌及其前驱病变的风险。
agLP的发病率为男性每10万人中有1.54例，女性每10万人中有1.36例。男女发病率之间无统计学差异（p = 0.5721）。外阴高级别鳞状上皮内病变（HSIL）的比值比（OR）为31.2（95%置信区间 = 2.46 - 1645.00；p = 0.01）。阴茎肿瘤的OR无法计算，因为对照患者无肿瘤，但差异提示有统计学意义（95%置信区间 = 1.90 - 无穷大；p = 0.008）。女性agLP患者诊断时的平均年龄为59.9岁（中位数62岁），男性患者为40.8岁（中位数33岁）。女性和男性患者的平均年龄差异有统计学意义（95%置信区间 = 11.92 - 26.13；p < 0.001）。
agLP患者发生外阴HSIL和阴茎肿瘤的风险可能增加。
