Kamata K, Rebec G V
Brain Res. 1985 Apr 15;332(1):188-93. doi: 10.1016/0006-8993(85)90406-8.
Single-unit activity was recorded in the substantia nigra pars reticulata of rats in response to intravenous challenge injections of D-amphetamine. The animals were pretreated with saline or 5.0 mg/kg D-amphetamine twice daily for 6 consecutive days. Whereas the large majority of saline controls (6 of 8) showed no consistent responses to amphetamine at doses up to 2.0 mg/kg, amphetamine pretreated rats (7 of 10) responded with a progressive increase in firing rate. Both groups of animals responded to a subsequent injection of 5.0 mg/kg clozapine with a depression of firing rate. The remaining control rats were inhibited by amphetamine and this aberrant response was enhanced with long-term treatment. In these unusual cells, clozapine accelerated firing rate. Taken together, these results indicate that unlike dopaminergic neurons in the compacta region of the nigra, reticulata neurons increase their responsiveness to amphetamine with repeated administration.
记录大鼠黑质网状部的单单位活动，以响应静脉注射D-苯丙胺的激发注射。动物每天两次用生理盐水或5.0mg/kg D-苯丙胺预处理，连续6天。虽然绝大多数生理盐水对照组（8只中的6只）在剂量高达2.0mg/kg时对苯丙胺没有一致的反应，但苯丙胺预处理的大鼠（10只中的7只）的反应是放电率逐渐增加。两组动物对随后注射5.0mg/kg氯氮平均有放电率降低的反应。其余对照大鼠被苯丙胺抑制，这种异常反应在长期治疗后增强。在这些异常细胞中，氯氮平加快了放电率。综上所述，这些结果表明，与黑质致密部的多巴胺能神经元不同，网状部神经元在重复给药后对苯丙胺的反应性增加。
