Anderson G D, Rebec G V
Pharmacol Biochem Behav. 1986 Jun;24(6):1561-6. doi: 10.1016/0091-3057(86)90485-5.
Rats were pretreated with saline or with behaviorally equivalent doses of clozapine (10.0 mg/kg) or haloperidol (1.0 mg/kg) twice daily for six consecutive days. On the following day, amygdaloid neurons in clozapine-pretreated rats responded to a challenge injection of this drug with a significantly greater increase in firing rate than saline controls. In contrast, amygdaloid neurons generally remained unresponsive to haloperidol even when pretreatment with this drug was extended to 13 days. Neither clozapine nor haloperidol pretreatment, however, altered the response of amygdaloid neurons to d-amphetamine administered after a four-day washout period. Amphetamine inhibited amygdaloid activity to a comparable extent in all rats. Taken together, these results implicate the amygdaloid complex as an important site of action of clozapine and related antischizophrenic drugs.
大鼠连续六天每天两次接受生理盐水、行为等效剂量的氯氮平（10.0毫克/千克）或氟哌啶醇（1.0毫克/千克）预处理。在接下来的一天，经氯氮平预处理的大鼠杏仁核神经元对该药物的激发注射反应，其放电率的增加显著大于生理盐水对照组。相比之下，即使将氟哌啶醇预处理延长至13天，杏仁核神经元通常对其仍无反应。然而，氯氮平和氟哌啶醇预处理均未改变在四天洗脱期后给予的d-苯丙胺对杏仁核神经元的反应。苯丙胺在所有大鼠中对杏仁核活动的抑制程度相当。综上所述，这些结果表明杏仁核复合体是氯氮平和相关抗精神分裂症药物的重要作用部位。
