Rezapanah Alireza, Ebrahimi Parisa, Sherafati Hamzeh, Dalili Amin, Jangjoo Ali, Emadzadeh Maryam, Parhizgar Pooyan
Surgical Oncology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of General Surgery, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Langenbecks Arch Surg. 2025 Feb 14;410(1):71. doi: 10.1007/s00423-025-03644-5.
The prevalence of obesity is increasing globally, necessitating effective treatment strategies. The effectiveness of Metabolic and Bariatric surgery (MBS) as a therapeutic option across different age groups remains debated. This study aimed to compare the outcomes and complications of MBS in patients less than 50 years old and 50 years or older.
This retrospective study analyzed data from patients who underwent MBS in a referral hospital in Mashhad, Iran, between April 2012 and March 2017. The recorded follow-up information was included for patients with at least six months post-surgery.
The study included 709 patients, 519 patients aged ≤ 50 years, and 190 patients > 50. The average age, weight, and BMI of the participants were 42.7 ± 13.24 years, 126.6 ± 31.23 kg, and 47.2 ± 10.37 kg/m2, respectively. Both age groups demonstrated significant improvements in BMI, cholesterol, and TG levels post-surgery, while significant improvements in FBS levels were observed only in the younger group (p < 0.05). Overall, substantial reductions in the prevalence of obesity-related comorbidity were observed in both age groups post-surgery (p < 0.05). None of the post-surgical complications had a statistically significant difference between the two age groups (p > 0.05).
MBS is effective in reducing obesity-related comorbidities, regardless of age. Age should not be a limiting factor for MBS, as the benefits and complications do not differ significantly between patients under and over 50 years old.
全球肥胖患病率正在上升，因此需要有效的治疗策略。代谢与减重手术（MBS）作为一种治疗选择在不同年龄组中的有效性仍存在争议。本研究旨在比较年龄小于50岁和50岁及以上患者接受MBS后的结局和并发症。
这项回顾性研究分析了2012年4月至2017年3月期间在伊朗马什哈德一家转诊医院接受MBS治疗的患者数据。记录了术后至少六个月患者的随访信息。
该研究纳入了709例患者，其中519例年龄≤50岁，190例年龄>50岁。参与者的平均年龄、体重和BMI分别为42.7±13.24岁、126.6±31.23 kg和47.2±10.37 kg/m²。两个年龄组术后BMI、胆固醇和甘油三酯水平均有显著改善，而仅在较年轻组中观察到空腹血糖水平有显著改善（p<0.05）。总体而言，两个年龄组术后肥胖相关合并症的患病率均大幅降低（p<0.05）。两个年龄组之间术后并发症均无统计学显著差异（p>0.05）。
无论年龄大小，MBS在降低肥胖相关合并症方面均有效。年龄不应成为MBS的限制因素，因为50岁以下和50岁以上患者的获益和并发症并无显著差异。
