Ts'ao C, Eisenstein R
Prostaglandins Med. 1979 Sep;3(3):159-66. doi: 10.1016/0161-4630(79)90099-5.
The individual and combined effects of PGD2, PGI2 and an aortic proteoglycan on human platelet aggregation and plasma clotting were studied. PGI2 was at least 10 times more potent than PGD2 in inhibiting platelet aggregation. Small doses of prostaglandins inhibited ADP- and thrombin-induced aggregation, but only prolonged aggregation time without affecting the extent of arachidonic acid (AA)-induced aggregation. Small doses of prostaglandins did not affect thrombin-induced clotting of PRP. Large doses of prostaglandins abolished platelet aggregation and prolonged the onset of thrombin-induced clotting. The aortic proteoglycan (APG) had no appreciable effect on ADP- or AA-induced aggregation. Small doses of APG abolished thrombin-induced clotting, while large doses of APG suppressed both clotting and aggregation induced by thrombin. PGI2 and PGD2 showed additive inhibition of platelet aggregation regardless how the aggregation was induced. APG and prostaglandins showed additive inhibition of only thrombin-induced aggregation. APG, but not any of the prostaglandins, prolonged clotting time of PPP. This prolongation was not potentiated by PGI2 or PGD2.
研究了前列腺素D2（PGD2）、前列腺素I2（PGI2）和一种主动脉蛋白聚糖对人血小板聚集和血浆凝血的单独及联合作用。PGI2在抑制血小板聚集方面的效力至少是PGD2的10倍。小剂量前列腺素可抑制二磷酸腺苷（ADP）和凝血酶诱导的聚集，但仅延长聚集时间，而不影响花生四烯酸（AA）诱导的聚集程度。小剂量前列腺素不影响凝血酶诱导的富血小板血浆（PRP）凝血。大剂量前列腺素可消除血小板聚集并延长凝血酶诱导凝血的起始时间。主动脉蛋白聚糖（APG）对ADP或AA诱导的聚集没有明显影响。小剂量APG可消除凝血酶诱导的凝血，而大剂量APG可抑制凝血酶诱导的凝血和聚集。无论聚集如何诱导，PGI2和PGD2对血小板聚集均表现出相加抑制作用。APG和前列腺素仅对凝血酶诱导的聚集表现出相加抑制作用。APG可延长血小板贫乏血浆（PPP）的凝血时间，而前列腺素则无此作用。PGI2或PGD2不会增强这种延长作用。
