前列腺素对兔血小板电泳迁移率和聚集的影响。
Influences of prostaglandins on electrophoretic mobility and aggregation of rabbit platelets.
作者信息
Takano S, Itagaki S, Sakurai K, Suzuki T
出版信息
Prostaglandins. 1980 Sep;20(3):579-86. doi: 10.1016/0090-6980(80)90045-3.
Influences of prostaglandin (PG)s on electrophoretic mobilities and aggregation of rabbit platelets were studied. The PGs studied (PGI2, PGE1, PGD2, PGF2 alpha, PGA2 and PGA1) had no effect on platelet electrophoretic mobility. However, both PGE1 and PGI2 in 0.3 and 3.0 muM inhibited ADP-induced aggregation and ADP-induced decrease in the mobility. PGD2 in 0.3 and 3.0, and PGE2 in 30 microM inhibited the aggregation but did not depress the ADP-induced decrease in the mobility. PGF2 alpha, PGA2 and PGA1 had no effect on the decrease in electrophoretic mobility and on the aggregation caused by ADP.
研究了前列腺素（PG）对兔血小板电泳迁移率和聚集的影响。所研究的前列腺素（前列环素I2、前列腺素E1、前列腺素D2、前列腺素F2α、前列腺素A2和前列腺素A1）对血小板电泳迁移率无影响。然而，0.3和3.0μM的前列腺素E1和前列环素I2均抑制二磷酸腺苷（ADP）诱导的聚集以及ADP诱导的迁移率降低。0.3和3.0μM的前列腺素D2以及30μM的前列腺素E2抑制聚集，但不抑制ADP诱导的迁移率降低。前列腺素F2α、前列腺素A2和前列腺素A1对电泳迁移率降低以及ADP引起的聚集均无影响。
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