Brunjes P C
Brain Res Bull. 1985 Mar;14(3):233-7. doi: 10.1016/0361-9230(85)90088-7.
Unilateral olfactory deprivation on Day 1 results in large reduction in olfactory bulb size when animals are examined in the juvenile period. The present study explored 2 issues. First, the development of changes in laminar volume was measured in order to determine when differences in olfactory bulb size emerge. Rat pups underwent surgical closure of one naris on Day 1 and laminar sizes were examined on either day 4, 8, or 12. Reliable differences emerged between "deprived" and control bulbs by Day 12. Second, to determine the length of the period of susceptibility to changes in sensory input, pups were deprived on either Day 10 or 20 and reared for thirty days. Deprivation at both ages reduced bulb size, although treatment at the later age resulted in less severe alterations.
在第1天进行单侧嗅觉剥夺，当在幼年期检查动物时，嗅球大小会大幅减小。本研究探讨了两个问题。第一，测量层体积变化的发展情况，以确定嗅球大小差异何时出现。出生第1天的幼鼠接受一侧鼻孔手术封闭，并在第4、8或12天检查层大小。到第12天，“剥夺组”和对照组嗅球之间出现了可靠的差异。第二，为了确定对感觉输入变化敏感的时期长度，幼鼠在第10天或第20天进行剥夺，并饲养30天。两个年龄段的剥夺都减小了嗅球大小，尽管较晚年龄段的处理导致的改变较轻。
