Dalfen R, Calhoun K, Gilas T, Mathews T, Falk M, Moffat F L, Makowka L, Rotstein L E, Langer J C, Venturi D
Cancer. 1985 Jun 1;55(11):2737-40. doi: 10.1002/1097-0142(19850601)55:11<2737::aid-cncr2820551137>3.0.co;2-f.
Local recurrence after radical surgery is a major problem with many primary solid cancers. The use of radiofrequency hyperthermia (RFHT) as adjuvant therapy to surgery was explored in the Fischer bladder carcinoma (FBCa)/F344 rat tumor system. After subcutaneous innoculation of 34 rats with 10(6) FBCa cells in suspension, RFHT was administered to 17 animals on days 1, 5, 8, and 12. The development of palpable tumors was delayed but not prevented, and tumor growth was retarded in RFHT-treated animals. In another experiment 40 rats were innoculated by subcutaneous trocar injection with a 1 mm3 piece of FBCa. After tumor excision on day 17, adjuvant therapy (untreated control, mitomycin C, RFHT, or RFHT plus mitomycin C) was started on day 20 (10 rats/treatment). The 20 RFHT-treated rats had only 1 incisional recurrence as compared to 9 recurrences in sham-heated rats (P less than 0.005). The authors conclude that RFHT has considerable value as adjuvant therapy to surgery in these tumors. Additional studies of RFHT as adjuvant treatment after surgical excision of tumors are planned.
根治性手术后的局部复发是许多原发性实体癌的一个主要问题。在Fischer膀胱癌（FBCa）/F344大鼠肿瘤系统中探索了使用射频热疗（RFHT）作为手术辅助治疗的方法。给34只大鼠皮下接种10⁶个悬浮的FBCa细胞后，在第1、5、8和12天对17只动物进行RFHT治疗。可触及肿瘤的出现延迟但未被阻止，且RFHT治疗的动物肿瘤生长受到抑制。在另一项实验中，通过皮下套管针注射1mm³的FBCa对40只大鼠进行接种。在第17天肿瘤切除后，于第20天开始辅助治疗（未治疗的对照组、丝裂霉素C、RFHT或RFHT加丝裂霉素C，每组10只大鼠）。20只接受RFHT治疗的大鼠仅有1例切口复发，而假加热大鼠有9例复发（P＜0.005）。作者得出结论，RFHT作为这些肿瘤手术的辅助治疗具有相当大的价值。计划对RFHT作为肿瘤手术切除后的辅助治疗进行更多研究。
